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Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors

 Ki-Bum Won  ;  Ran Heo  ;  Hyung-Bok Park  ;  Byoung Kwon Lee  ;  Fay Y Lin  ;  Martin Hadamitzky  ;  Yong-Jin Kim  ;  Ji Min Sung  ;  Edoardo Conte  ;  Daniele Andreini  ;  Gianluca Pontone  ;  Matthew J Budoff  ;  Ilan Gottlieb  ;  Eun Ju Chun  ;  Filippo Cademartiri  ;  Erica Maffei  ;  Hugo Marques  ;  Pedro de Araújo Gonçalves  ;  Jonathon A Leipsic  ;  Sang-Eun Lee  ;  Sanghoon Shin  ;  Jung Hyun Choi  ;  Renu Virmani  ;  Habib Samady  ;  Kavitha Chinnaiyan  ;  Daniel S Berman  ;  Jagat Narula  ;  Leslee J Shaw  ;  Jeroen J Bax  ;  James K Min  ;  Hyuk-Jae Chang 
 ATHEROSCLEROSIS, Vol.324 : 46-51, 2021-03 
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Atherogenic index of plasma ; Atherosclerosis ; Coronary artery disease ; Coronary computed tomography angiography
Background and aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma atherogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA). Methods: A total of 1488 adults (60.9 ± 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concentrations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) ≥1.0%/year. All participants were divided into three groups based on AIP tertiles. Results: Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02-2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV. Conclusions: Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
Heo, Ran(허란)
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