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Atherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors

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dc.contributor.author이병권-
dc.contributor.author장혁재-
dc.contributor.author허란-
dc.date.accessioned2021-05-26T16:50:42Z-
dc.date.available2021-05-26T16:50:42Z-
dc.date.issued2021-03-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182860-
dc.description.abstractBackground and aims: The atherogenic index of plasma (AIP) has been suggested as a marker of plasma atherogenicity. This study aimed to assess the association between AIP and the rapid progression of coronary atherosclerosis using serial coronary computed tomography angiography (CCTA). Methods: A total of 1488 adults (60.9 ± 9.2 years, 58.9% male) who underwent serial CCTA with a median inter-scan period of 3.4 years were included. AIP was defined as the base 10 logarithm of the ratio of the concentrations of triglyceride to high-density lipoprotein cholesterol. Rapid plaque progression (RPP) was defined as the change of percentage atheroma volume (PAV) ≥1.0%/year. All participants were divided into three groups based on AIP tertiles. Results: Baseline total PAV (median [interquartile range (IQR)]) (%) (group I [lowest]: 1.91 [0.00, 6.21] vs. group II: 2.82 [0.27, 8.83] vs. group III [highest]: 2.70 [0.41, 7.50]), the annual change of total PAV (median [IQR]) (%/year) (group I: 0.27 [0.00, 0.81] vs. group II: 0.37 [0.04, 1.11] vs. group III: 0.45 [0.06, 1.25]), and the incidence of RPP (group I: 19.7% vs. group II: 27.3% vs. group III: 31.4%) were significantly different among AIP tertiles (all p < 0.05). In multiple logistic regression analysis, the risk of RPP was increased in group III (odds ratio: 1.52, 95% confidence interval: 1.02-2.26; p = 0.042) compared to group I after adjusting for clinical factors and baseline total PAV. Conclusions: Based on serial CCTA findings, AIP is an independent predictive marker for RPP beyond traditional risk factors.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfATHEROSCLEROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAtherogenic index of plasma and the risk of rapid progression of coronary atherosclerosis beyond traditional risk factors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorKi-Bum Won-
dc.contributor.googleauthorRan Heo-
dc.contributor.googleauthorHyung-Bok Park-
dc.contributor.googleauthorByoung Kwon Lee-
dc.contributor.googleauthorFay Y Lin-
dc.contributor.googleauthorMartin Hadamitzky-
dc.contributor.googleauthorYong-Jin Kim-
dc.contributor.googleauthorJi Min Sung-
dc.contributor.googleauthorEdoardo Conte-
dc.contributor.googleauthorDaniele Andreini-
dc.contributor.googleauthorGianluca Pontone-
dc.contributor.googleauthorMatthew J Budoff-
dc.contributor.googleauthorIlan Gottlieb-
dc.contributor.googleauthorEun Ju Chun-
dc.contributor.googleauthorFilippo Cademartiri-
dc.contributor.googleauthorErica Maffei-
dc.contributor.googleauthorHugo Marques-
dc.contributor.googleauthorPedro de Araújo Gonçalves-
dc.contributor.googleauthorJonathon A Leipsic-
dc.contributor.googleauthorSang-Eun Lee-
dc.contributor.googleauthorSanghoon Shin-
dc.contributor.googleauthorJung Hyun Choi-
dc.contributor.googleauthorRenu Virmani-
dc.contributor.googleauthorHabib Samady-
dc.contributor.googleauthorKavitha Chinnaiyan-
dc.contributor.googleauthorDaniel S Berman-
dc.contributor.googleauthorJagat Narula-
dc.contributor.googleauthorLeslee J Shaw-
dc.contributor.googleauthorJeroen J Bax-
dc.contributor.googleauthorJames K Min-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.identifier.doi10.1016/j.atherosclerosis.2021.03.009-
dc.contributor.localIdA02793-
dc.contributor.localIdA03490-
dc.contributor.localIdA04348-
dc.relation.journalcodeJ00260-
dc.identifier.eissn1879-1484-
dc.identifier.pmid33813155-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0021915021001179-
dc.subject.keywordAtherogenic index of plasma-
dc.subject.keywordAtherosclerosis-
dc.subject.keywordCoronary artery disease-
dc.subject.keywordCoronary computed tomography angiography-
dc.contributor.alternativeNameLee, Byoung Kwon-
dc.contributor.affiliatedAuthor이병권-
dc.contributor.affiliatedAuthor장혁재-
dc.contributor.affiliatedAuthor허란-
dc.citation.volume324-
dc.citation.startPage46-
dc.citation.endPage51-
dc.identifier.bibliographicCitationATHEROSCLEROSIS, Vol.324 : 46-51, 2021-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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