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Analysis of Adverse Drug Reactions with Carbamazepine and Oxcarbazepine at a Tertiary Care Hospital

Authors
 Jung Eun Lee  ;  Kang Ryul Min  ;  Soo Hyun Kim  ;  Alec Hyungtack Kim  ;  Seong Taek Kim 
Citation
 YONSEI MEDICAL JOURNAL, Vol.61(10) : 875-879, 2020-10 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2020-10
MeSH
Adolescent ; Adult ; Aged ; Anticonvulsants / adverse effects* ; Anticonvulsants / therapeutic use ; Bipolar Disorder ; Carbamazepine / adverse effects* ; Carbamazepine / therapeutic use ; Drug-Related Side Effects and Adverse Reactions / epidemiology* ; Epilepsy / drug therapy ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Neuralgia ; Oxcarbazepine / adverse effects* ; Oxcarbazepine / therapeutic use ; Pharmacovigilance ; Republic of Korea / epidemiology ; Tertiary Care Centers ; Young Adult
Keywords
Carbamazepine ; anticonvulsants ; drug related adverse reactions ; oxcarbazepine
Abstract
Purpose: To describe adverse drug reactions (ADRs) to carbamazepine (CBZ) and oxcarbazepine (OXC), including severe cutaneous ADRs, at a tertiary care hospital over a 10-year period. Materials and methods: The frequency and clinical features of ADRs caused by CBZ and OXC were analyzed using the pharmacovigilance database and spontaneous ADR reporting data of Yonsei University Severance Hospital & Dental Hospital (Seoul, Korea) from January 1, 2010 to January 31, 2020. Results: Among 10419 cases prescribed CBZ and OXC, 204 ADR cases were reported. The incidences of ADRs were 1.8% and 2.2% for CBZ and OXC respectively, with no significant difference (p=0.169). The most common clinical presentations were skin disorders. Female patients had relatively more frequent ADRs than male patients. Although mild skin ADRs were more frequent with OXC, nervous system disorders, general disorders, and hepatobiliary disorders occurred more often with CBZ. There were six reports of severe cutaneous adverse reactions to CBZ, while OXC had none. Both CBZ and OXC caused ADRs at daily doses lower than the recommended initial dose. Conclusion: Due to lower incidence of severe ADRs with OXC than CBZ, we suggest OXC as a first-line prescription.
Files in This Item:
T202006349.pdf Download
DOI
10.3349/ymj.2020.61.10.875
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Taek(김성택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182623
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