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Analysis of Adverse Drug Reactions with Carbamazepine and Oxcarbazepine at a Tertiary Care Hospital
DC Field | Value | Language |
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dc.contributor.author | 김성택 | - |
dc.date.accessioned | 2021-05-21T16:56:13Z | - |
dc.date.available | 2021-05-21T16:56:13Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182623 | - |
dc.description.abstract | Purpose: To describe adverse drug reactions (ADRs) to carbamazepine (CBZ) and oxcarbazepine (OXC), including severe cutaneous ADRs, at a tertiary care hospital over a 10-year period. Materials and methods: The frequency and clinical features of ADRs caused by CBZ and OXC were analyzed using the pharmacovigilance database and spontaneous ADR reporting data of Yonsei University Severance Hospital & Dental Hospital (Seoul, Korea) from January 1, 2010 to January 31, 2020. Results: Among 10419 cases prescribed CBZ and OXC, 204 ADR cases were reported. The incidences of ADRs were 1.8% and 2.2% for CBZ and OXC respectively, with no significant difference (p=0.169). The most common clinical presentations were skin disorders. Female patients had relatively more frequent ADRs than male patients. Although mild skin ADRs were more frequent with OXC, nervous system disorders, general disorders, and hepatobiliary disorders occurred more often with CBZ. There were six reports of severe cutaneous adverse reactions to CBZ, while OXC had none. Both CBZ and OXC caused ADRs at daily doses lower than the recommended initial dose. Conclusion: Due to lower incidence of severe ADRs with OXC than CBZ, we suggest OXC as a first-line prescription. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Anticonvulsants / adverse effects* | - |
dc.subject.MESH | Anticonvulsants / therapeutic use | - |
dc.subject.MESH | Bipolar Disorder | - |
dc.subject.MESH | Carbamazepine / adverse effects* | - |
dc.subject.MESH | Carbamazepine / therapeutic use | - |
dc.subject.MESH | Drug-Related Side Effects and Adverse Reactions / epidemiology* | - |
dc.subject.MESH | Epilepsy / drug therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neuralgia | - |
dc.subject.MESH | Oxcarbazepine / adverse effects* | - |
dc.subject.MESH | Oxcarbazepine / therapeutic use | - |
dc.subject.MESH | Pharmacovigilance | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Tertiary Care Centers | - |
dc.subject.MESH | Young Adult | - |
dc.title | Analysis of Adverse Drug Reactions with Carbamazepine and Oxcarbazepine at a Tertiary Care Hospital | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) | - |
dc.contributor.googleauthor | Jung Eun Lee | - |
dc.contributor.googleauthor | Kang Ryul Min | - |
dc.contributor.googleauthor | Soo Hyun Kim | - |
dc.contributor.googleauthor | Alec Hyungtack Kim | - |
dc.contributor.googleauthor | Seong Taek Kim | - |
dc.identifier.doi | 10.3349/ymj.2020.61.10.875 | - |
dc.contributor.localId | A00588 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 32975062 | - |
dc.subject.keyword | Carbamazepine | - |
dc.subject.keyword | anticonvulsants | - |
dc.subject.keyword | drug related adverse reactions | - |
dc.subject.keyword | oxcarbazepine | - |
dc.contributor.alternativeName | Kim, Seong Taek | - |
dc.contributor.affiliatedAuthor | 김성택 | - |
dc.citation.volume | 61 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 875 | - |
dc.citation.endPage | 879 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.61(10) : 875-879, 2020-10 | - |
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