Cited 0 times in
Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 손혜영 | - |
dc.contributor.author | 윤선진 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2021-05-21T16:48:02Z | - |
dc.date.available | 2021-05-21T16:48:02Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182566 | - |
dc.description.abstract | Ferroptosis is an iron-dependent regulated necrosis mediated by lipid peroxidation. Cancer cells survive under metabolic stress conditions by altering lipid metabolism, which may alter their sensitivity to ferroptosis. However, the association between lipid metabolism and ferroptosis is not completely understood. In this study, we found that the expression of elongation of very long-chain fatty acid protein 5 (ELOVL5) and fatty acid desaturase 1 (FADS1) is up-regulated in mesenchymal-type gastric cancer cells (GCs), leading to ferroptosis sensitization. In contrast, these enzymes are silenced by DNA methylation in intestinal-type GCs, rendering cells resistant to ferroptosis. Lipid profiling and isotope tracing analyses revealed that intestinal-type GCs are unable to generate arachidonic acid (AA) and adrenic acid (AdA) from linoleic acid. AA supplementation of intestinal-type GCs restores their sensitivity to ferroptosis. Based on these data, the polyunsaturated fatty acid (PUFA) biosynthesis pathway plays an essential role in ferroptosis; thus, this pathway potentially represents a marker for predicting the efficacy of ferroptosis-mediated cancer therapy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | National Academy of Sciences | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Arachidonic Acid / genetics | - |
dc.subject.MESH | Arachidonic Acid / metabolism | - |
dc.subject.MESH | Arachidonic Acid / pharmacology | - |
dc.subject.MESH | Carbolines / pharmacology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | DNA Methylation | - |
dc.subject.MESH | Enhancer Elements, Genetic | - |
dc.subject.MESH | Fatty Acid Desaturases / genetics | - |
dc.subject.MESH | Fatty Acid Desaturases / metabolism | - |
dc.subject.MESH | Fatty Acid Elongases / genetics | - |
dc.subject.MESH | Fatty Acid Elongases / metabolism | - |
dc.subject.MESH | Fatty Acids, Unsaturated / biosynthesis* | - |
dc.subject.MESH | Fatty Acids, Unsaturated / genetics | - |
dc.subject.MESH | Fatty Acids, Unsaturated / metabolism | - |
dc.subject.MESH | Ferroptosis / drug effects | - |
dc.subject.MESH | Ferroptosis / genetics | - |
dc.subject.MESH | Ferroptosis / physiology* | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipid Metabolism / genetics | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Stomach Neoplasms / drug therapy | - |
dc.subject.MESH | Stomach Neoplasms / genetics* | - |
dc.subject.MESH | Stomach Neoplasms / metabolism* | - |
dc.subject.MESH | Stomach Neoplasms / pathology | - |
dc.title | Polyunsaturated fatty acid biosynthesis pathway determines ferroptosis sensitivity in gastric cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | BioMedical Science Institute (의생명과학부) | - |
dc.contributor.googleauthor | Ji-Yoon Lee | - |
dc.contributor.googleauthor | Miso Nam | - |
dc.contributor.googleauthor | Hye Young Son | - |
dc.contributor.googleauthor | Kwangbeom Hyun | - |
dc.contributor.googleauthor | Seo Young Jang | - |
dc.contributor.googleauthor | Jong Woo Kim | - |
dc.contributor.googleauthor | Min Wook Kim | - |
dc.contributor.googleauthor | Youngae Jung | - |
dc.contributor.googleauthor | Eunji Jang | - |
dc.contributor.googleauthor | Seon-Jin Yoon | - |
dc.contributor.googleauthor | Jungeun Kim | - |
dc.contributor.googleauthor | Jihye Kim | - |
dc.contributor.googleauthor | Jinho Seo | - |
dc.contributor.googleauthor | Jeong-Ki Min | - |
dc.contributor.googleauthor | Kyoung-Jin Oh | - |
dc.contributor.googleauthor | Baek-Soo Han | - |
dc.contributor.googleauthor | Won Kon Kim | - |
dc.contributor.googleauthor | Kwang-Hee Bae | - |
dc.contributor.googleauthor | Jaewhan Song | - |
dc.contributor.googleauthor | Jaehoon Kim | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Geum-Sook Hwang | - |
dc.contributor.googleauthor | Eun-Woo Lee | - |
dc.contributor.googleauthor | Sang Chul Lee | - |
dc.identifier.doi | 10.1073/pnas.2006828117 | - |
dc.contributor.localId | A04589 | - |
dc.contributor.localId | A05256 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 33288688 | - |
dc.identifier.url | https://www.pnas.org/content/117/51/32433.long | - |
dc.subject.keyword | ELOVL5 | - |
dc.subject.keyword | FADS1 | - |
dc.subject.keyword | arachidonic acid | - |
dc.subject.keyword | ferroptosis | - |
dc.subject.keyword | lipid peroxidation | - |
dc.contributor.alternativeName | Son, Hye Yeong | - |
dc.contributor.affiliatedAuthor | 손혜영 | - |
dc.contributor.affiliatedAuthor | 윤선진 | - |
dc.contributor.affiliatedAuthor | 허용민 | - |
dc.citation.volume | 117 | - |
dc.citation.number | 51 | - |
dc.citation.startPage | 32433 | - |
dc.citation.endPage | 32442 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.117(51) : 32433-32442, 2020-12 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.