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The Role of MSCs in the Tumor Microenvironment and Tumor Progression

Authors
 Sung Yong Ahn 
Citation
 ANTICANCER RESEARCH, Vol.40(6) : 3039-3047, 2020-06 
Journal Title
 ANTICANCER RESEARCH 
ISSN
 0250-7005 
Issue Date
2020-06
MeSH
Cell Differentiation ; Disease Progression ; Humans ; Mesenchymal Stem Cells / metabolism* ; Tumor Microenvironment
Keywords
Mesenchymal stem cells ; review ; tumor microenvironment ; tumor progression
Abstract
Over the past few decades, longevity without disease has become an important topic worldwide. However, as life expectancy increases, the number of patients with cancer is also increasing. Tumor progression is related to interactions between tumor cells and mesenchymal stem cells (MSCs) in the tumor microenvironment. MSCs are multipotent stromal cells known to be present in a variety of locations in the body, including bones, cartilage, fat, muscles, and dental pulp. MSCs migrate toward inflamed areas during pathological immune responses. MSCs also migrate toward tumor stroma and participate in tumor progression. MSCs can contribute to tumor progression by interacting with tumor cells via paracrine signaling and differentiate into diverse cell types. This also enables MSCs to make direct contact with tumor cells in tumor stroma. Interactions between tumor cells and MSCs enhance tumorigenic and metastatic potential, in addition to stimulating epithelial to mesenchymal transition. Herein, we reviewed the research associated with the tumor-enhancing role of MSCs in tumor progression, from primary tumor growth to distant tumor metastasis.
Full Text
https://ar.iiarjournals.org/content/40/6/3039.long
DOI
10.21873/anticanres.14284
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sung Yong(안성용) ORCID logo https://orcid.org/0000-0002-6029-1853
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182481
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