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Anhedonia Relates to the Altered Global and Local Grey Matter Network Properties in Schizophrenia

Authors
 Byung-Hoon Kim  ;  Hesun Erin Kim  ;  Jung Suk Lee  ;  Jae-Jin Kim 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.10(7) : 1395, 2021-04 
Journal Title
 JOURNAL OF CLINICAL MEDICINE 
Issue Date
2021-04
Keywords
anhedonia ; graph theory ; grey matter network ; schizophrenia
Abstract
Anhedonia is one of the major negative symptoms in schizophrenia and defined as the loss of hedonic experience to various stimuli in real life. Although structural magnetic resonance imaging has provided a deeper understanding of anhedonia-related abnormalities in schizophrenia, network analysis of the grey matter focusing on this symptom is lacking. In this study, single-subject grey matter networks were constructed in 123 patients with schizophrenia and 160 healthy controls. The small-world property of the grey matter network and its correlations with the level of physical and social anhedonia were evaluated using graph theory analysis. In the global scale whole-brain analysis, the patients showed reduced small-world property of the grey matter network. The local-scale analysis further revealed reduced small-world property in the default mode network, salience/ventral attention network, and visual network. The regional-level analysis showed an altered relationship between the small-world properties and the social anhedonia scale scores in the cerebellar lobule in patients with schizophrenia. These results indicate that anhedonia in schizophrenia may be related to abnormalities in the grey matter network at both the global whole-brain scale and local-regional scale.
Files in This Item:
T202101172.pdf Download
DOI
10.3390/jcm10071395
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182417
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