Cited 2 times in
Anhedonia Relates to the Altered Global and Local Grey Matter Network Properties in Schizophrenia
DC Field | Value | Language |
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dc.contributor.author | 김재진 | - |
dc.date.accessioned | 2021-04-29T17:34:46Z | - |
dc.date.available | 2021-04-29T17:34:46Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182417 | - |
dc.description.abstract | Anhedonia is one of the major negative symptoms in schizophrenia and defined as the loss of hedonic experience to various stimuli in real life. Although structural magnetic resonance imaging has provided a deeper understanding of anhedonia-related abnormalities in schizophrenia, network analysis of the grey matter focusing on this symptom is lacking. In this study, single-subject grey matter networks were constructed in 123 patients with schizophrenia and 160 healthy controls. The small-world property of the grey matter network and its correlations with the level of physical and social anhedonia were evaluated using graph theory analysis. In the global scale whole-brain analysis, the patients showed reduced small-world property of the grey matter network. The local-scale analysis further revealed reduced small-world property in the default mode network, salience/ventral attention network, and visual network. The regional-level analysis showed an altered relationship between the small-world properties and the social anhedonia scale scores in the cerebellar lobule in patients with schizophrenia. These results indicate that anhedonia in schizophrenia may be related to abnormalities in the grey matter network at both the global whole-brain scale and local-regional scale. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Anhedonia Relates to the Altered Global and Local Grey Matter Network Properties in Schizophrenia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | Byung-Hoon Kim | - |
dc.contributor.googleauthor | Hesun Erin Kim | - |
dc.contributor.googleauthor | Jung Suk Lee | - |
dc.contributor.googleauthor | Jae-Jin Kim | - |
dc.identifier.doi | 10.3390/jcm10071395 | - |
dc.contributor.localId | A00870 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 33807226 | - |
dc.subject.keyword | anhedonia | - |
dc.subject.keyword | graph theory | - |
dc.subject.keyword | grey matter network | - |
dc.subject.keyword | schizophrenia | - |
dc.contributor.alternativeName | Kim, Jae Jin | - |
dc.contributor.affiliatedAuthor | 김재진 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1395 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.10(7) : 1395, 2021-04 | - |
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