9 15

Cited 0 times in

Solitary Fibrous Tumor/Hemangiopericytoma Metastasizes Extracranially, Associated with Altered Expression of WNT5A and MMP9

 Jong-Hwan Hong  ;  Myung-Giun Noh  ;  Md Rashedunnabi Akanda  ;  Yeong Jin Kim  ;  Se Hoon Kim  ;  Tae-Young Jung  ;  Shin Jung  ;  Jae-Hyuk Lee  ;  Joon Haeng Rhee  ;  Kyung-Keun Kim  ;  Sung Sun Kim  ;  Kyung-Hwa Lee  ;  Kyung-Sub Moon 
 CANCERS, Vol.13(5) : 1142, 2021-03 
Journal Title
Issue Date
gene expression profiling ; hemangiopericytoma ; immunohistochemistry ; neoplasm metastasis ; solitary fibrous tumors
Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a mesenchymal tumor originating from various soft tissues and meninges, which carries the NAB2-STAT6 fusion gene. Meningeal/intracranial SFT/HPCs (icSFT/HPC) have a poor clinical outcome with metastatic behavior compared to soft tissue/extracranial SFT/HPCs (exSFT/HPC), but the underlying genetic factors are unclear. Differentially expressed genes (DEGs) were analyzed by NanoString nCounter assay using RNA extracted from formalin-fixed paraffin-embedded (FFPE) tissue samples. Additionally, immunohistochemistry (IHC) was performed on 32 cases of exSFT/HPC, 18 cases of icSFT/HPC, and additional recurrent or metastatic cases to verify the findings. Pathway analysis revealed that the WNT signaling pathway was enriched in exSFT/HPC. Analysis of DEGs showed that expression of WNT5A was lower and that of MMP9 was higher in icSFT/HPC than in exSFT/HPC (p = 0.008 and p = 0.035, respectively). IHC showed that WNT5A and CD34 expression was high in exSFT/HPC (p < 0.001, both), while that of MMP9 was high in icSFT/HPC (p = 0.001). Expression of CLDN5 in tumoral vessels was locally decreased in icSFT/HPC (p < 0.001). The results suggested that decreased WNT5A expression, together with increased MMP9 expression, in icSFT/HPC, may affect vascular tightness and prompt tumor cells to metastasize extracranially.
Files in This Item:
T202101039.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.