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Solitary Fibrous Tumor/Hemangiopericytoma Metastasizes Extracranially, Associated with Altered Expression of WNT5A and MMP9

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dc.contributor.author김세훈-
dc.date.accessioned2021-04-29T17:26:51Z-
dc.date.available2021-04-29T17:26:51Z-
dc.date.issued2021-03-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182345-
dc.description.abstractSolitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a mesenchymal tumor originating from various soft tissues and meninges, which carries the NAB2-STAT6 fusion gene. Meningeal/intracranial SFT/HPCs (icSFT/HPC) have a poor clinical outcome with metastatic behavior compared to soft tissue/extracranial SFT/HPCs (exSFT/HPC), but the underlying genetic factors are unclear. Differentially expressed genes (DEGs) were analyzed by NanoString nCounter assay using RNA extracted from formalin-fixed paraffin-embedded (FFPE) tissue samples. Additionally, immunohistochemistry (IHC) was performed on 32 cases of exSFT/HPC, 18 cases of icSFT/HPC, and additional recurrent or metastatic cases to verify the findings. Pathway analysis revealed that the WNT signaling pathway was enriched in exSFT/HPC. Analysis of DEGs showed that expression of WNT5A was lower and that of MMP9 was higher in icSFT/HPC than in exSFT/HPC (p = 0.008 and p = 0.035, respectively). IHC showed that WNT5A and CD34 expression was high in exSFT/HPC (p < 0.001, both), while that of MMP9 was high in icSFT/HPC (p = 0.001). Expression of CLDN5 in tumoral vessels was locally decreased in icSFT/HPC (p < 0.001). The results suggested that decreased WNT5A expression, together with increased MMP9 expression, in icSFT/HPC, may affect vascular tightness and prompt tumor cells to metastasize extracranially.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSolitary Fibrous Tumor/Hemangiopericytoma Metastasizes Extracranially, Associated with Altered Expression of WNT5A and MMP9-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorJong-Hwan Hong-
dc.contributor.googleauthorMyung-Giun Noh-
dc.contributor.googleauthorMd Rashedunnabi Akanda-
dc.contributor.googleauthorYeong Jin Kim-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorTae-Young Jung-
dc.contributor.googleauthorShin Jung-
dc.contributor.googleauthorJae-Hyuk Lee-
dc.contributor.googleauthorJoon Haeng Rhee-
dc.contributor.googleauthorKyung-Keun Kim-
dc.contributor.googleauthorSung Sun Kim-
dc.contributor.googleauthorKyung-Hwa Lee-
dc.contributor.googleauthorKyung-Sub Moon-
dc.identifier.doi10.3390/cancers13051142-
dc.contributor.localIdA00610-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid33799999-
dc.subject.keywordgene expression profiling-
dc.subject.keywordhemangiopericytoma-
dc.subject.keywordimmunohistochemistry-
dc.subject.keywordneoplasm metastasis-
dc.subject.keywordsolitary fibrous tumors-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.affiliatedAuthor김세훈-
dc.citation.volume13-
dc.citation.number5-
dc.citation.startPage1142-
dc.identifier.bibliographicCitationCANCERS, Vol.13(5) : 1142, 2021-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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