Cited 7 times in
Solitary Fibrous Tumor/Hemangiopericytoma Metastasizes Extracranially, Associated with Altered Expression of WNT5A and MMP9
DC Field | Value | Language |
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dc.contributor.author | 김세훈 | - |
dc.date.accessioned | 2021-04-29T17:26:51Z | - |
dc.date.available | 2021-04-29T17:26:51Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182345 | - |
dc.description.abstract | Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is a mesenchymal tumor originating from various soft tissues and meninges, which carries the NAB2-STAT6 fusion gene. Meningeal/intracranial SFT/HPCs (icSFT/HPC) have a poor clinical outcome with metastatic behavior compared to soft tissue/extracranial SFT/HPCs (exSFT/HPC), but the underlying genetic factors are unclear. Differentially expressed genes (DEGs) were analyzed by NanoString nCounter assay using RNA extracted from formalin-fixed paraffin-embedded (FFPE) tissue samples. Additionally, immunohistochemistry (IHC) was performed on 32 cases of exSFT/HPC, 18 cases of icSFT/HPC, and additional recurrent or metastatic cases to verify the findings. Pathway analysis revealed that the WNT signaling pathway was enriched in exSFT/HPC. Analysis of DEGs showed that expression of WNT5A was lower and that of MMP9 was higher in icSFT/HPC than in exSFT/HPC (p = 0.008 and p = 0.035, respectively). IHC showed that WNT5A and CD34 expression was high in exSFT/HPC (p < 0.001, both), while that of MMP9 was high in icSFT/HPC (p = 0.001). Expression of CLDN5 in tumoral vessels was locally decreased in icSFT/HPC (p < 0.001). The results suggested that decreased WNT5A expression, together with increased MMP9 expression, in icSFT/HPC, may affect vascular tightness and prompt tumor cells to metastasize extracranially. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Solitary Fibrous Tumor/Hemangiopericytoma Metastasizes Extracranially, Associated with Altered Expression of WNT5A and MMP9 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Jong-Hwan Hong | - |
dc.contributor.googleauthor | Myung-Giun Noh | - |
dc.contributor.googleauthor | Md Rashedunnabi Akanda | - |
dc.contributor.googleauthor | Yeong Jin Kim | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Tae-Young Jung | - |
dc.contributor.googleauthor | Shin Jung | - |
dc.contributor.googleauthor | Jae-Hyuk Lee | - |
dc.contributor.googleauthor | Joon Haeng Rhee | - |
dc.contributor.googleauthor | Kyung-Keun Kim | - |
dc.contributor.googleauthor | Sung Sun Kim | - |
dc.contributor.googleauthor | Kyung-Hwa Lee | - |
dc.contributor.googleauthor | Kyung-Sub Moon | - |
dc.identifier.doi | 10.3390/cancers13051142 | - |
dc.contributor.localId | A00610 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 33799999 | - |
dc.subject.keyword | gene expression profiling | - |
dc.subject.keyword | hemangiopericytoma | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | neoplasm metastasis | - |
dc.subject.keyword | solitary fibrous tumors | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | 김세훈 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1142 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.13(5) : 1142, 2021-03 | - |
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