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Lesions causing hallucinations localize to one common brain network

Authors
 Na Young Kim  ;  Joey Hsu  ;  Daniel Talmasov  ;  Juho Joutsa  ;  Louis Soussand  ;  Ona Wu  ;  Natalia S Rost  ;  Estrella Morenas-Rodríguez  ;  Joan Martí-Fàbregas  ;  Alvaro Pascual-Leone  ;  Philip R Corlett  ;  Michael D Fox 
Citation
 MOLECULAR PSYCHIATRY, Vol.26(4) : 1299-1309, 2021-04 
Journal Title
 MOLECULAR PSYCHIATRY 
ISSN
 1359-4184 
Issue Date
2021-04
Abstract
The brain regions responsible for hallucinations remain unclear. We studied 89 brain lesions causing hallucinations using a recently validated technique termed lesion network mapping. We found that hallucinations occurred following lesions to a variety of different brain regions, but these lesion locations fell within a single functionally connected brain network. This network was defined by connectivity to the cerebellar vermis, inferior cerebellum (bilateral lobule X), and the right superior temporal sulcus. Within this single hallucination network, additional connections with the lesion location dictated the sensory modality of the hallucination: lesions causing visual hallucinations were connected to the lateral geniculate nucleus in the thalamus while lesions causing auditory hallucinations were connected to the dentate nucleus in the cerebellum. Our results suggest that lesions causing hallucinations localize to a single common brain network, but additional connections within this network dictate the sensory modality, lending insight into the causal neuroanatomical substrate of hallucinations.
Full Text
https://www.nature.com/articles/s41380-019-0565-3
DOI
10.1038/s41380-019-0565-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Na Young(김나영) ORCID logo https://orcid.org/0000-0001-9888-3953
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182302
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