Cited 152 times in
Effect of Microvascular Invasion Risk on Early Recurrence of Hepatocellular Carcinoma After Surgery and Radiofrequency Ablation
DC Field | Value | Language |
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dc.contributor.author | 이선영 | - |
dc.date.accessioned | 2021-04-29T17:20:00Z | - |
dc.date.available | 2021-04-29T17:20:00Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 0003-4932 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182289 | - |
dc.description.abstract | Objective: We compared surgical resection (SR) and radiofrequency ablation (RFA) as first-line treatment in patients with hepatocellular carcinoma (HCC) based on the risk of microvascular invasion (MVI). Background: The best curative treatment modality between SR and RFA in patients with HCC with MVI remains unclear. Methods: Data from 2 academic cancer center-based cohorts of patients with a single, small (≤3 cm) HCC who underwent SR were used to derive (n = 276) and validate (n = 101) prediction models for MVI using clinical and imaging variables. The MVI prediction model was developed using multivariable logistic regression analysis and externally validated. Early recurrence (<2 years) based on risk stratification between SR (n = 276) and RFA (n = 240) was evaluated via propensity score matching. Results: In the multivariable analysis, alpha-fetoprotein (≥15 ng/mL), protein induced by vitamin K absence-II (≥48 mAU/mL), arterial peritumoral enhancement, and hepatobiliary peritumoral hypointensity on magnetic resonance imaging were associated with MVI. Incorporating these factors, the area under the receiver operating characteristic curve of the predictive model was 0.87 (95% confidence interval: 0.82-0.92) and 0.82 (95% confidence interval: 0.74-0.90) in the derivation and validation cohorts, respectively. SR was associated with a lower rate of early recurrence than RFA based on the risk of MVI after propensity score matching (P < 0.05). Conclusions: Our model predicted the risk of MVI in patients with a small (≤ 3 cm) HCC with high accuracy. Patients with MVI who had undergone RFA were more vulnerable to recurrence than those who had undergone SR. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | ANNALS OF SURGERY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Hepatocellular / diagnostic imaging | - |
dc.subject.MESH | Carcinoma, Hepatocellular / pathology* | - |
dc.subject.MESH | Carcinoma, Hepatocellular / surgery* | - |
dc.subject.MESH | Catheter Ablation* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms / diagnostic imaging | - |
dc.subject.MESH | Liver Neoplasms / pathology* | - |
dc.subject.MESH | Liver Neoplasms / surgery* | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplasm Recurrence, Local | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Propensity Score | - |
dc.subject.MESH | Registries | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Effect of Microvascular Invasion Risk on Early Recurrence of Hepatocellular Carcinoma After Surgery and Radiofrequency Ablation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Sunyoung Lee | - |
dc.contributor.googleauthor | Tae Wook Kang | - |
dc.contributor.googleauthor | Kyoung Doo Song | - |
dc.contributor.googleauthor | Min Woo Lee | - |
dc.contributor.googleauthor | Hyunchul Rhim | - |
dc.contributor.googleauthor | Hyo Keun Lim | - |
dc.contributor.googleauthor | So Yeon Kim | - |
dc.contributor.googleauthor | Dong Hyun Sinn | - |
dc.contributor.googleauthor | Jong Man Kim | - |
dc.contributor.googleauthor | Kyunga Kim | - |
dc.contributor.googleauthor | Sang Yun Ha | - |
dc.identifier.doi | 10.1097/SLA.0000000000003268 | - |
dc.contributor.localId | A05659 | - |
dc.relation.journalcode | J00178 | - |
dc.identifier.eissn | 1528-1140 ( | - |
dc.identifier.pmid | 31058694 | - |
dc.identifier.url | https://insights.ovid.com/pubmed?pmid=31058694 | - |
dc.contributor.alternativeName | Lee, Sunyoung | - |
dc.contributor.affiliatedAuthor | 이선영 | - |
dc.citation.volume | 273 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 564 | - |
dc.citation.endPage | 571 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGERY, Vol.273(3) : 564-571, 2021-03 | - |
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