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Triggering Receptor Expressed on Myeloid Cells-1 Agonist Regulates Intestinal Inflammation via Cd177 + Neutrophils

Authors
 Dong Hyuk Seo  ;  Xiumei Che  ;  Soochan Kim  ;  Da Hye Kim  ;  Hyun Woo Ma  ;  Jae Hyeon Kim  ;  Tae Il Kim  ;  Won Ho Kim  ;  Seung Won Kim  ;  Jae Hee Cheon 
Citation
 FRONTIERS IN IMMUNOLOGY, Vol.12 : 650864, 2021-03 
Journal Title
 FRONTIERS IN IMMUNOLOGY 
Issue Date
2021-03
Keywords
CD177 ; inflammatory bowel disease ; macrophage ; neutrophil ; triggering receptor expressed on myeloid cell
Abstract
Triggering receptor expressed on myeloid cell-1 (TREM-1) signaling is expressed on neutrophils and monocytes that is necessary for the successful antimicrobial response and resolution of inflammation in the gut. In this study, we determined the effect of an anti-TREM-1 agonistic antibody (α-TREM-1) on colitis and identify its underlying mechanism of action. Administration of α-TREM-1 alleviated colitis in mice and resolved dysbiosis, which required TLR4/Myd88 signaling. α-TREM-1 increased the production of neutrophil extracellular traps and interleukin-22 by CD177+ neutrophils, which led to pathogen clearance and protection of the intestinal barrier. TREM-1 activation using an α-TREM-1 antibody protects against colitis by rebalancing the microbiota and protecting the epithelium against the immune response as well as modulates the function of neutrophils and macrophages. These results highlight the importance of the TREM-1 pathway in intestinal homeostasis and suggest that α-TREM-1 treatment may be an effective therapeutic strategy for inflammatory bowel disease.
Files in This Item:
T202100876.pdf Download
DOI
10.3389/fimmu.2021.650864
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Won(김승원) ORCID logo https://orcid.org/0000-0002-1692-1192
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182267
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