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Extracellular Vesicles and Immune System in Ageing and Immune Diseases

Authors
 So Yeong Cheon  ;  Jong Eun Lee 
Citation
 EXPERIMENTAL NEUROBIOLOGY, Vol.30(1) : 32-47, 2021-02 
Journal Title
 EXPERIMENTAL NEUROBIOLOGY 
ISSN
 1226-2560 
Issue Date
2021-02
Keywords
Ageing ; Biomarkers ; Drug delivery system ; Extracellular vesicles ; Inflammatory disease
Abstract
Immune system is essential for host homeostasis. Immune cells communicate with each other by binding to receptors or by releasing vesicles including chemokines and cytokines. Under healthy circumstances, immune cell-derived factors are critical for cellular growth, division and function, whereas under conditions such as ageing and inflammatory states, they can aggravate pathologies and cause disease. Cell-derived membranous extracellular vesicles mediate cell-to-cell communication and are implicated in various physiological and pathological processes involving ageing and age-related diseases. Extracellular vesicles are responsible for spreading detrimental factors to the surroundings and the propagation phase of inflammatory diseases. The regulation of extracellular vesicles is a putative target for treatment of inflammatory diseases. Moreover, their features are ideal for developing biomarkers and drug delivery systems modulated by bioengineering in inflammatory diseases. The present review summarizes the current understanding of extracellular vesicles in ageing and inflammatory diseases.
Files in This Item:
T202100788.pdf Download
DOI
10.5607/en20059
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182242
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