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Transforming growth factor-β-regulated fractalkine as a marker of erosive bone invasion in oral squamous cell carcinoma

Authors
 Seung Hwa Son  ;  Junhee Park  ;  Min Ju Jung  ;  Sun Kyoung Lee  ;  Hyungkeun Kim  ;  Ki Rim Kim  ;  Kwang-Kyun Park  ;  Won-Yoon Chung 
Citation
 EUROPEAN JOURNAL OF ORAL SCIENCES, Vol.129(1) : e12750, 2021-02 
Journal Title
 EUROPEAN JOURNAL OF ORAL SCIENCES 
ISSN
 0909-8836 
Issue Date
2021-02
Keywords
TGF-β ; bone invasion ; fractalkine ; oral squamous cell carcinoma
Abstract
Patients with oral squamous cell carcinoma (OSCC) bone invasion are surgically treated with bone resection, which results in severe physical and psychological damage. Here, we investigated the potential of fractalkine (CX3CL1), which is regulated by transforming growth factor (TGF-β), as a novel biomarker for correct prediction and early detection of OSCC-associated bone invasion. TGF-β knockdown and treatment with a TGF-β-neutralizing antibody decreased the level of fractalkine in the culture media of HSC-2 and YD10B OSCC cells. Treatment with a fractalkine-neutralizing antibody reduced TGF-β-stimulated invasion by HSC-2 and YD10B cells. Fractalkine treatment increased the viability, invasion, and uPA secretion of both OSCC cell lines. Furthermore, OSCC cell bone invasion was assessed following subcutaneous inoculation of wild-type or TGF-β knockdown OSCC cells in mouse calvaria. TGF-β knockdown prevented erosive bone invasion, reduced the number of osteoclasts at the tumor-bone interface, and downregulated fractalkine expression in mouse tumor tissues. Our results indicate that the production of fractalkine is stimulated by TGF-β and mediates TGF-β-induced cell invasion in several OSCC cell lines showing an erosive pattern of bone invasion. Fractalkine may be a useful predictive marker and therapeutic target for OSCC-induced bone destruction.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/eos.12750
DOI
10.1111/eos.12750
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Kwang Kyun(박광균)
Park, Jun Hee(박준희)
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182240
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