507 358

Cited 12 times in

Performance of Prediction Models for Diagnosing Severe Aortic Stenosis Based on Aortic Valve Calcium on Cardiac Computed Tomography: Incorporation of Radiomics and Machine Learning

DC Field Value Language
dc.contributor.author김영진-
dc.contributor.author서영주-
dc.contributor.author최병욱-
dc.contributor.author한경화-
dc.date.accessioned2021-04-29T17:06:35Z-
dc.date.available2021-04-29T17:06:35Z-
dc.date.issued2021-03-
dc.identifier.issn1229-6929-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182186-
dc.description.abstractObjective: We aimed to develop a prediction model for diagnosing severe aortic stenosis (AS) using computed tomography (CT) radiomics features of aortic valve calcium (AVC) and machine learning (ML) algorithms. Materials and methods: We retrospectively enrolled 408 patients who underwent cardiac CT between March 2010 and August 2017 and had echocardiographic examinations (240 patients with severe AS on echocardiography [the severe AS group] and 168 patients without severe AS [the non-severe AS group]). Data were divided into a training set (312 patients) and a validation set (96 patients). Using non-contrast-enhanced cardiac CT scans, AVC was segmented, and 128 radiomics features for AVC were extracted. After feature selection was performed with three ML algorithms (least absolute shrinkage and selection operator [LASSO], random forests [RFs], and eXtreme Gradient Boosting [XGBoost]), model classifiers for diagnosing severe AS on echocardiography were developed in combination with three different model classifier methods (logistic regression, RF, and XGBoost). The performance (c-index) of each radiomics prediction model was compared with predictions based on AVC volume and score. Results: The radiomics scores derived from LASSO were significantly different between the severe AS and non-severe AS groups in the validation set (median, 1.563 vs. 0.197, respectively, p < 0.001). A radiomics prediction model based on feature selection by LASSO + model classifier by XGBoost showed the highest c-index of 0.921 (95% confidence interval [CI], 0.869-0.973) in the validation set. Compared to prediction models based on AVC volume and score (c-indexes of 0.894 [95% CI, 0.815-0.948] and 0.899 [95% CI, 0.820-0.951], respectively), eight and three of the nine radiomics prediction models showed higher discrimination abilities for severe AS. However, the differences were not statistically significant (p > 0.05 for all). Conclusion: Models based on the radiomics features of AVC and ML algorithms may perform well for diagnosing severe AS, but the added value compared to AVC volume and score should be investigated further.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society of Radiology-
dc.relation.isPartOfKOREAN JOURNAL OF RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAortic Valve / diagnostic imaging*-
dc.subject.MESHAortic Valve / metabolism-
dc.subject.MESHAortic Valve Stenosis / diagnosis*-
dc.subject.MESHAortic Valve Stenosis / diagnostic imaging-
dc.subject.MESHAortic Valve Stenosis / pathology-
dc.subject.MESHCalcium / metabolism*-
dc.subject.MESHEchocardiography-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMachine Learning*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTomography, X-Ray Computed-
dc.titlePerformance of Prediction Models for Diagnosing Severe Aortic Stenosis Based on Aortic Valve Calcium on Cardiac Computed Tomography: Incorporation of Radiomics and Machine Learning-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorNam Gyu Kang-
dc.contributor.googleauthorYoung Joo Suh-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorYoung Jin Kim-
dc.contributor.googleauthorByoung Wook Choi-
dc.identifier.doi10.3348/kjr.2020.0099-
dc.contributor.localIdA00727-
dc.contributor.localIdA01892-
dc.contributor.localIdA04059-
dc.relation.journalcodeJ02884-
dc.identifier.eissn2005-8330-
dc.identifier.pmid33236537-
dc.subject.keywordAortic stenosis-
dc.subject.keywordAortic valve calcium-
dc.subject.keywordComputed tomography-
dc.subject.keywordMachine learning-
dc.subject.keywordRadiomics-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.affiliatedAuthor김영진-
dc.contributor.affiliatedAuthor서영주-
dc.contributor.affiliatedAuthor최병욱-
dc.citation.volume22-
dc.citation.number3-
dc.citation.startPage334-
dc.citation.endPage343-
dc.identifier.bibliographicCitationKOREAN JOURNAL OF RADIOLOGY, Vol.22(3) : 334-343, 2021-03-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.