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Correlation between serum carbohydrate antigen 19-9 levels and computed tomography severity score in patients with nontuberculous mycobacterial pulmonary disease
DC Field | Value | Language |
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dc.contributor.author | 강영애 | - |
dc.contributor.author | 김송이 | - |
dc.contributor.author | 김영삼 | - |
dc.contributor.author | 김은영 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 이상훈 | - |
dc.contributor.author | 이수환 | - |
dc.contributor.author | 이혜정 | - |
dc.contributor.author | 임아영 | - |
dc.contributor.author | 정경수 | - |
dc.contributor.author | 정지예 | - |
dc.date.accessioned | 2021-04-29T17:02:59Z | - |
dc.date.available | 2021-04-29T17:02:59Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182155 | - |
dc.description.abstract | There is no validated clinical biomarker for disease severity or treatment response for nontuberculous mycobacterial pulmonary disease (NTM-PD). We investigated the correlation between elevated serum carbohydrate antigen (CA) 19-9 levels and NTM-PD disease activity, defined using an imaging severity score based on chest computed tomography (CT). We retrospectively examined 79 patients with NTM-PD who underwent serum CA19-9 level assessments and chest CT less than 1 month apart. NTM-PD severity was rated using a CT-based scoring system. The correlation between the CT score and serum CA19-9 levels was evaluated. Chest CT revealed nodular bronchiectasis without cavitation in most patients (78.5%). Serum CA19-9 levels were elevated in 19 (24%) patients. Serum CA19-9 levels were positively correlated with the total CT score and bronchiectasis, bronchiolitis, cavity, and consolidation subscores. Partial correlation analysis revealed a significant positive correlation between serum CA19-9 levels and CT scores for total score and bronchiectasis, bronchiolitis, cavitation, and consolidation subscores after controlling for age, sex, and BMI. Serum CA19-9 levels were positively correlated with the CT severity score for NTM-PD. Serum CA19-9 may be useful in evaluating disease activity or therapeutic response in patients with NTM-PD. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Correlation between serum carbohydrate antigen 19-9 levels and computed tomography severity score in patients with nontuberculous mycobacterial pulmonary disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Kangjoon Kim | - |
dc.contributor.googleauthor | Seung Hyun Yong | - |
dc.contributor.googleauthor | Su Hwan Lee | - |
dc.contributor.googleauthor | Sang Hoon Lee | - |
dc.contributor.googleauthor | Ah Young Leem | - |
dc.contributor.googleauthor | Song Yee Kim | - |
dc.contributor.googleauthor | Kyungsoo Chung | - |
dc.contributor.googleauthor | Eun Young Kim | - |
dc.contributor.googleauthor | Ji Ye Jung | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Young Sam Kim | - |
dc.contributor.googleauthor | Hye-Jeong Lee | - |
dc.contributor.googleauthor | Young Ae Kang | - |
dc.identifier.doi | 10.1038/s41598-021-82363-5 | - |
dc.contributor.localId | A00057 | - |
dc.contributor.localId | A00626 | - |
dc.contributor.localId | A00707 | - |
dc.contributor.localId | A00811 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A02836 | - |
dc.contributor.localId | A02904 | - |
dc.contributor.localId | A03320 | - |
dc.contributor.localId | A03382 | - |
dc.contributor.localId | A03570 | - |
dc.contributor.localId | A03735 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 33531571 | - |
dc.contributor.alternativeName | Kang, Young Ae | - |
dc.contributor.affiliatedAuthor | 강영애 | - |
dc.contributor.affiliatedAuthor | 김송이 | - |
dc.contributor.affiliatedAuthor | 김영삼 | - |
dc.contributor.affiliatedAuthor | 김은영 | - |
dc.contributor.affiliatedAuthor | 박무석 | - |
dc.contributor.affiliatedAuthor | 이상훈 | - |
dc.contributor.affiliatedAuthor | 이수환 | - |
dc.contributor.affiliatedAuthor | 이혜정 | - |
dc.contributor.affiliatedAuthor | 임아영 | - |
dc.contributor.affiliatedAuthor | 정경수 | - |
dc.contributor.affiliatedAuthor | 정지예 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 2777 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.11(1) : 2777, 2021-02 | - |
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