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p-Coumaric Acid Enhances Hypothalamic Leptin Signaling and Glucose Homeostasis in Mice via Differential Effects on AMPK Activation

Authors
 Linh V Nguyen  ;  Khoa D A Nguyen  ;  Chi-Thanh Ma  ;  Quoc-Thai Nguyen  ;  Huong T H Nguyen  ;  Dong-Joo Yang  ;  Trung Le Tran  ;  Ki Woo Kim  ;  Khanh V Doan 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(3) : 1431, 2021-02 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2021-02
Keywords
AMPK ; HFD-induced obesity ; glucose homeostasis ; leptin signaling ; p-Coumaric acid
Abstract
AMP-activated protein kinase (AMPK) plays a crucial role in the regulation of energy homeostasis in both peripheral metabolic organs and the central nervous system. Recent studies indicated that p-Coumaric acid (CA), a hydroxycinnamic phenolic acid, potentially activated the peripheral AMPK pathway to exert beneficial effects on glucose metabolism in vitro. However, CA's actions on central AMPK activity and whole-body glucose homeostasis have not yet been investigated. Here, we reported that CA exhibited different effects on peripheral and central AMPK activation both in vitro and in vivo. Specifically, while CA treatment promoted hepatic AMPK activation, it showed an inhibitory effect on hypothalamic AMPK activity possibly by activating the S6 kinase. Furthermore, CA treatment enhanced hypothalamic leptin sensitivity, resulting in increased proopiomelanocortin (POMC) expression, decreased agouti-related peptide (AgRP) expression, and reduced daily food intake. Overall, CA treatment improved blood glucose control, glucose tolerance, and insulin sensitivity. Together, these results suggested that CA treatment enhanced hypothalamic leptin signaling and whole-body glucose homeostasis, possibly via its differential effects on AMPK activation.
Files in This Item:
T202100493.pdf Download
DOI
10.3390/ijms22031431
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Woo(김기우) ORCID logo https://orcid.org/0000-0002-7790-1515
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182148
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