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Differentiation of left atrial appendage thrombus from circulatory stasis using cardiac CT radiomics in patients with valvular heart disease

DC Field Value Language
dc.contributor.author김영진-
dc.contributor.author서영주-
dc.contributor.author심지영-
dc.contributor.author이삭-
dc.contributor.author이승현-
dc.contributor.author최병욱-
dc.contributor.author홍그루-
dc.date.accessioned2021-04-29T16:56:51Z-
dc.date.available2021-04-29T16:56:51Z-
dc.date.issued2021-02-
dc.identifier.issn0938-7994-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182101-
dc.description.abstractObjectives: To determine whether quantitative radiomic features from cardiac CT could differentiate the left atrial appendage (LAA) thrombus from circulatory stasis in patients with valvular heart disease. Methods: Ninety-five consecutive patients with valvular heart disease and filling defects in LAA on two-phase cardiac CT from March 2016 to August 2018 were retrospectively enrolled and classified as having thrombus or stasis by transesophageal echocardiography or cardiac surgery. The ratio of Hounsfield units in the filling defects to those in the ascending aorta (AA) was calculated on early- and late-phase CT (LAA/AAE and LAA/AAL, respectively). Radiomic features were extracted from semi-automated three-dimensional segmentation of the filling defect on early-phase CT. The diagnostic ability of radiomic features for differentiating thrombus from stasis was assessed and compared to LAA/AAE and LAA/AAL by comparing the AUC of ROC curves. Diagnostic performances of CT attenuation ratios and radiomic features were validated with an independent validation set. Results: Thrombus was diagnosed in 25 cases and stasis in 70. Sixty-eight radiomic features were extracted. Values of 8 wavelet-transformed features were lower in thrombus than in stasis (p < 0.001). The AUC value of a radiomic feature, wavelet_LHL, for diagnosing thrombus was 0.78, which was higher than that of LAA/AAE (AUC = 0.54, p = 0.025) and similar to that of LAA/AAL (AUC = 0.76, p = 0.773). In the validation set, the AUC of wavelet_LHL was 0.71, which was higher than that of LAA/AAE (AUC = 0.57, p = 0.391) and similar to that of LAA/AAL (AUC = 0.75, p = 0.707). Conclusions: Quantitative radiomic features from the early phase of cardiac CT may help diagnose LAA thrombus in patients with valvular heart disease. Key points: • Wavelet-transformed grey-level non-uniformity values from radiomic analysis are significantly lower for LAA thrombus than for circulatory stasis. • Radiomic features may have an additional value for differentiating LAA thrombus from circulatory stasis when interpreting single-phase cardiac CT. • Radiomic features extracted from single-phase images may show similar diagnostic ability as conventional quantitative analysis from two-phase images.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfEUROPEAN RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAtrial Appendage* / diagnostic imaging-
dc.subject.MESHAtrial Fibrillation*-
dc.subject.MESHEchocardiography, Transesophageal-
dc.subject.MESHHeart Valve Diseases* / complications-
dc.subject.MESHHeart Valve Diseases* / diagnostic imaging-
dc.subject.MESHHumans-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHThrombosis* / diagnostic imaging-
dc.subject.MESHTomography, X-Ray Computed-
dc.titleDifferentiation of left atrial appendage thrombus from circulatory stasis using cardiac CT radiomics in patients with valvular heart disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorSei Hyun Chun-
dc.contributor.googleauthorYoung Joo Suh-
dc.contributor.googleauthorKyunghwa Han-
dc.contributor.googleauthorSang Joon Park-
dc.contributor.googleauthorChi Young Shim-
dc.contributor.googleauthorGeu-Ru Hong-
dc.contributor.googleauthorSak Lee-
dc.contributor.googleauthorSeung-Hyun Lee-
dc.contributor.googleauthorYoung Jin Kim-
dc.contributor.googleauthorByoung Wook Choi-
dc.identifier.doi10.1007/s00330-020-07173-1-
dc.contributor.localIdA00727-
dc.contributor.localIdA01892-
dc.contributor.localIdA02213-
dc.contributor.localIdA02807-
dc.contributor.localIdA02935-
dc.contributor.localIdA04059-
dc.contributor.localIdA04386-
dc.relation.journalcodeJ00851-
dc.identifier.eissn1432-1084-
dc.identifier.pmid32812175-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00330-020-07173-1-
dc.subject.keywordAtrial appendage-
dc.subject.keywordHeart valve diseases-
dc.subject.keywordMultidetector computed tomography-
dc.subject.keywordThrombosis-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.affiliatedAuthor김영진-
dc.contributor.affiliatedAuthor서영주-
dc.contributor.affiliatedAuthor심지영-
dc.contributor.affiliatedAuthor이삭-
dc.contributor.affiliatedAuthor이승현-
dc.contributor.affiliatedAuthor최병욱-
dc.contributor.affiliatedAuthor홍그루-
dc.citation.volume31-
dc.citation.number2-
dc.citation.startPage1130-
dc.citation.endPage1139-
dc.identifier.bibliographicCitationEUROPEAN RADIOLOGY, Vol.31(2) : 1130-1139, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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