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Upregulation of LAMB1 via ERK/c-Jun Axis Promotes Gastric Cancer Growth and Motility

Authors
 Hana Lee  ;  Won-Jin Kim  ;  Hyeon-Gu Kang  ;  Jun-Ho Jang  ;  Il Ju Choi  ;  Kyung-Hee Chun  ;  Seok-Jun Kim 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(2) : 626, 2021-01 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2021-01
MeSH
Adenocarcinoma / diagnosis ; Adenocarcinoma / genetics* ; Adenocarcinoma / metabolism ; Adenocarcinoma / physiopathology ; Cell Line, Tumor ; Cell Movement* ; Cell Proliferation* ; Extracellular Signal-Regulated MAP Kinases / metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Laminin / genetics* ; Laminin / metabolism ; Laminin / physiology ; MAP Kinase Signaling System ; Prognosis ; Proto-Oncogene Proteins c-jun / metabolism ; Stomach Neoplasms / diagnosis ; Stomach Neoplasms / genetics* ; Stomach Neoplasms / metabolism ; Stomach Neoplasms / physiopathology
Keywords
ERK/c-Jun/LAMB1 axis ; cell motility ; cell proliferation ; gastric cancer ; laminin subunit beta 1 (LAMB1)
Abstract
Gastric cancer is the fifth most common cancer worldwide with a poor survival rate. Therefore, it is important to identify predictive and prognostic biomarkers of gastric cancer. Laminin subunit beta 1 (LAMB1) is involved in attachment, migration, and organization during development, and its elevated expression has been associated with several cancers. However, the role and mechanism of LAMB1 in gastric cancer remains unknown. Here, we determined that LAMB1 is upregulated in gastric cancer tissues and contributes to cell growth and motility. Using a public database, we showed that LAMB1 expression was significantly upregulated in gastric cancer compared to normal tissues. LAMB1 was also found to be associated with poor prognosis in patients with gastric cancer. Overexpression of LAMB1 elevated cell proliferation, invasion, and migration; however, knockdown of LAMB1 decreased these effects in gastric cancer cells. U0126, an extracellular signal-regulated kinase (ERK) inhibitor, regulated the expression of LAMB1 in gastric cancer cells. Additionally, we showed that c-Jun directly binds to the LAMB1 promoter as a transcription factor and regulates its gene expression via the ERK pathway in gastric cancer cells. Therefore, our study indicates that LAMB1 promotes cell growth and motility via the ERK/c-Jun axis and is a potential biomarker and therapeutic target of gastric cancer.
Files in This Item:
T202100394.pdf Download
DOI
10.3390/ijms22020626
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Chun, Kyung Hee(전경희) ORCID logo https://orcid.org/0000-0002-9867-7321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182089
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