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Upregulation of LAMB1 via ERK/c-Jun Axis Promotes Gastric Cancer Growth and Motility

DC Field Value Language
dc.contributor.author전경희-
dc.date.accessioned2021-04-29T16:55:24Z-
dc.date.available2021-04-29T16:55:24Z-
dc.date.issued2021-01-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182089-
dc.description.abstractGastric cancer is the fifth most common cancer worldwide with a poor survival rate. Therefore, it is important to identify predictive and prognostic biomarkers of gastric cancer. Laminin subunit beta 1 (LAMB1) is involved in attachment, migration, and organization during development, and its elevated expression has been associated with several cancers. However, the role and mechanism of LAMB1 in gastric cancer remains unknown. Here, we determined that LAMB1 is upregulated in gastric cancer tissues and contributes to cell growth and motility. Using a public database, we showed that LAMB1 expression was significantly upregulated in gastric cancer compared to normal tissues. LAMB1 was also found to be associated with poor prognosis in patients with gastric cancer. Overexpression of LAMB1 elevated cell proliferation, invasion, and migration; however, knockdown of LAMB1 decreased these effects in gastric cancer cells. U0126, an extracellular signal-regulated kinase (ERK) inhibitor, regulated the expression of LAMB1 in gastric cancer cells. Additionally, we showed that c-Jun directly binds to the LAMB1 promoter as a transcription factor and regulates its gene expression via the ERK pathway in gastric cancer cells. Therefore, our study indicates that LAMB1 promotes cell growth and motility via the ERK/c-Jun axis and is a potential biomarker and therapeutic target of gastric cancer.-
dc.description.statementOfResponsibilityopen-
dc.languageINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.publisherINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdenocarcinoma / diagnosis-
dc.subject.MESHAdenocarcinoma / genetics*-
dc.subject.MESHAdenocarcinoma / metabolism-
dc.subject.MESHAdenocarcinoma / physiopathology-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHCell Movement*-
dc.subject.MESHCell Proliferation*-
dc.subject.MESHExtracellular Signal-Regulated MAP Kinases / metabolism-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHLaminin / genetics*-
dc.subject.MESHLaminin / metabolism-
dc.subject.MESHLaminin / physiology-
dc.subject.MESHMAP Kinase Signaling System-
dc.subject.MESHPrognosis-
dc.subject.MESHProto-Oncogene Proteins c-jun / metabolism-
dc.subject.MESHStomach Neoplasms / diagnosis-
dc.subject.MESHStomach Neoplasms / genetics*-
dc.subject.MESHStomach Neoplasms / metabolism-
dc.subject.MESHStomach Neoplasms / physiopathology-
dc.titleUpregulation of LAMB1 via ERK/c-Jun Axis Promotes Gastric Cancer Growth and Motility-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Biochemistry and Molecular Biology (생화학-분자생물학교실)-
dc.contributor.googleauthorHana Lee-
dc.contributor.googleauthorWon-Jin Kim-
dc.contributor.googleauthorHyeon-Gu Kang-
dc.contributor.googleauthorJun-Ho Jang-
dc.contributor.googleauthorIl Ju Choi-
dc.contributor.googleauthorKyung-Hee Chun-
dc.contributor.googleauthorSeok-Jun Kim-
dc.identifier.doi10.3390/ijms22020626-
dc.contributor.localIdA03501-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid33435161-
dc.subject.keywordERK/c-Jun/LAMB1 axis-
dc.subject.keywordcell motility-
dc.subject.keywordcell proliferation-
dc.subject.keywordgastric cancer-
dc.subject.keywordlaminin subunit beta 1 (LAMB1)-
dc.contributor.alternativeNameChun, Kyung Hee-
dc.contributor.affiliatedAuthor전경희-
dc.citation.volume22-
dc.citation.number2-
dc.citation.startPage626-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(2) : 626, 2021-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers

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