0 21

Cited 0 times in

Central precocious puberty may be a manifestation of endocrine dysfunction in pediatric patients with mitochondrial disease

Authors
 Hyun-Wook Chae  ;  Ji-Hoon Na  ;  Ahreum Kwon  ;  Ho-Seong Kim  ;  Young-Mock Lee 
Citation
 EUROPEAN JOURNAL OF PEDIATRICS, Vol.180(2) : 425-432, 2021-02 
Journal Title
EUROPEAN JOURNAL OF PEDIATRICS
ISSN
 0340-6199 
Issue Date
2021-02
Keywords
Estradiol ; Growth ; Mitochondrial diseases ; Precocious puberty
Abstract
We retrospectively reviewed the data of 140 female pediatric patients with rare mitochondrial diseases (MDs) confirmed using muscle biopsy. We evaluated patients who were diagnosed with central precocious puberty (PP) with early pubertal development to determine whether PP is a clinical manifestation of MDs. We also examined the clinical, auxiological, laboratory, and radiological parameters after 1 year of gonadotropin-releasing hormone treatment for central PP. Among the 140 girls with MDs, 29 had early pubertal development and underwent endocrine evaluation. Ten (7.1%) patients were diagnosed with central PP; the prevalence of central PP was higher than was that previously thought. Patients with central PP exhibited bone age advancement over 1 year and increased sex hormone levels despite their young age at diagnosis. Serum estradiol levels were significantly higher in younger patients than in older patients (P = 0.004). Patients with central PP treated with gonadotropin-releasing hormone had favorable outcomes, and their pubertal development was suppressed for 1 year.Conclusion: Central PP may be a manifestation of endocrine dysfunction in young girls with MDs. What is Known: • The general characteristics of mitochondrial diseases include developmental delays and retarded growth. • Precocious puberty has rarely been suggested as a clinical manifestation of mitochondrial diseases. What is New: • Among the 140 girls with mitochondrial diseases, 10 (7.1%) were diagnosed with central precocious puberty. • Serum estradiol levels were significantly higher in younger patients than in older patients.
Full Text
https://link.springer.com/article/10.1007%2Fs00431-020-03804-3
DOI
10.1007/s00431-020-03804-3
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Kwon, Ah Reum(권아름) ORCID logo https://orcid.org/0000-0002-9692-2135
Kim, Ho Seong(김호성) ORCID logo https://orcid.org/0000-0003-1135-099X
Na, Ji Hoon(나지훈) ORCID logo https://orcid.org/0000-0002-3051-2010
Lee, Young Mock(이영목) ORCID logo https://orcid.org/0000-0002-5838-249X
Chae, Hyun Wook(채현욱) ORCID logo https://orcid.org/0000-0001-5016-8539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182084
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links