Cited 3 times in
Central precocious puberty may be a manifestation of endocrine dysfunction in pediatric patients with mitochondrial disease
DC Field | Value | Language |
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dc.contributor.author | 권아름 | - |
dc.contributor.author | 김호성 | - |
dc.contributor.author | 이영목 | - |
dc.contributor.author | 채현욱 | - |
dc.contributor.author | 나지훈 | - |
dc.date.accessioned | 2021-04-29T16:54:49Z | - |
dc.date.available | 2021-04-29T16:54:49Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0340-6199 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182084 | - |
dc.description.abstract | We retrospectively reviewed the data of 140 female pediatric patients with rare mitochondrial diseases (MDs) confirmed using muscle biopsy. We evaluated patients who were diagnosed with central precocious puberty (PP) with early pubertal development to determine whether PP is a clinical manifestation of MDs. We also examined the clinical, auxiological, laboratory, and radiological parameters after 1 year of gonadotropin-releasing hormone treatment for central PP. Among the 140 girls with MDs, 29 had early pubertal development and underwent endocrine evaluation. Ten (7.1%) patients were diagnosed with central PP; the prevalence of central PP was higher than was that previously thought. Patients with central PP exhibited bone age advancement over 1 year and increased sex hormone levels despite their young age at diagnosis. Serum estradiol levels were significantly higher in younger patients than in older patients (P = 0.004). Patients with central PP treated with gonadotropin-releasing hormone had favorable outcomes, and their pubertal development was suppressed for 1 year.Conclusion: Central PP may be a manifestation of endocrine dysfunction in young girls with MDs. What is Known: • The general characteristics of mitochondrial diseases include developmental delays and retarded growth. • Precocious puberty has rarely been suggested as a clinical manifestation of mitochondrial diseases. What is New: • Among the 140 girls with mitochondrial diseases, 10 (7.1%) were diagnosed with central precocious puberty. • Serum estradiol levels were significantly higher in younger patients than in older patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English, German | - |
dc.publisher | Springer Verlag | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PEDIATRICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Central precocious puberty may be a manifestation of endocrine dysfunction in pediatric patients with mitochondrial disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | ;Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Hyun-Wook Chae | - |
dc.contributor.googleauthor | Ji-Hoon Na | - |
dc.contributor.googleauthor | Ahreum Kwon | - |
dc.contributor.googleauthor | Ho-Seong Kim | - |
dc.contributor.googleauthor | Young-Mock Lee | - |
dc.identifier.doi | 10.1007/s00431-020-03804-3 | - |
dc.contributor.localId | A00228 | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A02955 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J00839 | - |
dc.identifier.eissn | 1432-1076 | - |
dc.identifier.pmid | 32914201 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00431-020-03804-3 | - |
dc.subject.keyword | Estradiol | - |
dc.subject.keyword | Growth | - |
dc.subject.keyword | Mitochondrial diseases | - |
dc.subject.keyword | Precocious puberty | - |
dc.contributor.alternativeName | Kwon, Ah Reum | - |
dc.contributor.affiliatedAuthor | 권아름 | - |
dc.contributor.affiliatedAuthor | 김호성 | - |
dc.contributor.affiliatedAuthor | 이영목 | - |
dc.contributor.affiliatedAuthor | 채현욱 | - |
dc.citation.volume | 180 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 425 | - |
dc.citation.endPage | 432 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PEDIATRICS, Vol.180(2) : 425-432, 2021-02 | - |
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