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A laboratory study to detect simulated pulpal blood flow in extracted human teeth using ultrasound Doppler flowmetry

Authors
 M J Yoon  ;  D H Kim  ;  I Y Jung  ;  S H Park 
Citation
 INTERNATIONAL ENDODONTIC JOURNAL, Vol.54(2) : 231-240, 2021-02 
Journal Title
 INTERNATIONAL ENDODONTIC JOURNAL 
ISSN
 0143-2885 
Issue Date
2021-02
MeSH
Dental Pulp* / diagnostic imaging ; Humans ; Laboratories* ; Laser-Doppler Flowmetry ; Regional Blood Flow ; Rheology ; Ultrasonography
Keywords
Doppler ultrasound ; Doppler ultrasound phantom ; microfluidics ; pulpal blood flow ; pulpal blood flow velocity
Abstract
Aim: To develop a laboratory-based tooth model of simulated blood flow in teeth and evaluate it using ultrasound Doppler flowmetry (UDF). Methodology: A laboratory-based tooth model for UDF was created based on a microfluidic experimental model proposed by Kim & Park (2016 a,b). Twenty-one maxillary or mandibular anterior human teeth within 1 month of extraction were used. Four holes were made in each tooth to fit 1.6-mm diameter polytetrafluoroethylene (PTFE) tubes: at the apical foramen, palatal surface in the centre of the crown, palatal surface apical to the cementoenamel junction (CEJ) and the root centre. Fluid mimicking pulsating blood was pumped (pressure range: 0-200 mbar, flow rate range: 0-80 μL min-1 ) into the apical foramen via the PTFE tubes, which exited the tooth through the palatal surface in the centre of the crown (control group), palatal surface below the CEJ (group 1) and the palatal surface at the mid-root level (group 2). An UDF transducer of 20 MHz was placed at a 60° angle to the labial surface of tooth and was used to measure the fluid flow velocity (Vs, Vas, Vm, Vam, Vd, Vad and Vakd). The flow velocity of the different groups was compared using the Wilcoxon signed-rank test, with a 95% confidence level. Results: UDF facilitated the detection of the simulated pulpal blood flow in the control group and group 1, but not in group 2. The mean and standard deviations of Vas, Vam and Vakd were 0.921 ± 0.394, 0.479 ± 0.208 and 0.396 ± 0.220 cm s-1 , respectively, in the control group, and 0.865 ± 0.368, 0.424 ± 0.215 and 0.487 ± 0.279 cm s-1 , respectively, in group 1. The pulpal blood flow values of the control group and group 1 were not significantly different (p > 0.05). Conclusions: This laboratory study revealed that ultrasound Doppler flowmetry enabled the detection of simulated blood flow below the level of the CEJ but not at the mid-root level.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/iej.13410
DOI
10.1111/iej.13410
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dohyun(김도현) ORCID logo https://orcid.org/0000-0002-0772-6985
Park, Sung Ho(박성호) ORCID logo https://orcid.org/0000-0003-2171-235X
Jung, Il Young(정일영) ORCID logo https://orcid.org/0000-0001-8972-2664
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182082
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