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Durable Oral Biofilm Resistance of 3D-Printed Dental Base Polymers Containing Zwitterionic Materials

Authors
 Jae-Sung Kwon  ;  Ji-Yeong Kim  ;  Utkarsh Mangal  ;  Ji-Young Seo  ;  Myung-Jin Lee  ;  Jie Jin  ;  Jae-Hun Yu  ;  Sung-Hwan Choi 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(1) : 417, 2021-01 
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Issue Date
2021-01
MeSH
Bacterial Adhesion ; Biocompatible Materials / pharmacology* ; Biofilms / drug effects* ; Biofilms / growth & development ; Composite Resins / chemistry* ; Dental Materials / pharmacology* ; Humans ; Materials Testing ; Methacrylates / chemistry ; Mouth / drug effects* ; Mouth / microbiology ; Phosphorylcholine / analogs & derivatives ; Phosphorylcholine / chemistry ; Polymers / chemistry* ; Printing, Three-Dimensional / instrumentation* ; Streptococcus mutans / drug effects ; Streptococcus mutans / metabolism
Keywords
3D printing ; dental base resin ; dentistry ; durability ; oral salivary biofilm ; poly(methyl methacralyate) ; zwitterion
Abstract
Poly(methyl methacralyate) (PMMA) has long been used in dentistry as a base polymer for dentures, and it is recently being used for the 3D printing of dental materials. Despite its many advantages, its susceptibility to microbial colonization remains to be overcome. In this study, the interface between 3D-printed PMMA specimens and oral salivary biofilm was studied following the addition of zwitterionic materials, 2-methacryloyloxyethyl phosphorylcholine (MPC) or sulfobetaine methacrylate (SB). A significant reduction in bacterial and biofilm adhesions was observed following the addition of MPC or SB, owing to their protein-repellent properties, and there were no significant differences between the two test materials. Although the mechanical properties of the tested materials were degraded, the statistical value of the reduction was minimal and all the properties fulfilled the requirements set by the International Standard, ISO 20795-2. Additionally, both the test materials maintained their resistance to biofilm when subjected to hydrothermal fatigue, with no further deterioration of the mechanical properties. Thus, novel 3D-printable PMMA incorporated with MPC or SB shows durable oral salivary biofilm resistance with maintenance of the physical and mechanical properties.
Files in This Item:
T202100149.pdf Download
DOI
10.3390/ijms22010417
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181985
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