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Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort

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dc.contributor.author박병진-
dc.contributor.author이용제-
dc.contributor.author이혜선-
dc.date.accessioned2021-04-29T16:43:26Z-
dc.date.available2021-04-29T16:43:26Z-
dc.date.issued2021-02-
dc.identifier.issn1931-5244-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181982-
dc.description.abstractThe rate of undiagnosed type 2 diabetes tends to increase in lean Koreans, while the triglyceride glucose (TyG) index has been proposed as a surrogate marker of peripheral insulin resistance. We investigated the longitudinal relationship between TyG and incident type 2 diabetes among apparently healthy Korean adults. We assessed 4285 lean adults without diabetes aged 40-69 years from the Korean Genome and Epidemiology Study. Participants were divided into 4 groups according to quartiles of TyG index, calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. We prospectively assessed the hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes, based on the American Diabetes Association criteria, using multivariate Cox proportional hazards regression models, over 12 years after the baseline survey. During the follow-up period, 631 (14.7%) participants had newly developed type 2 diabetes. The HRs of incident type 2 diabetes in each TyG index quartile were 1.00, 1.63 (95%CI, 1.18-2.24), 2.30 (95%CI, 1.68-3.14), and 3.67 (95%CI, 2.71-4.98), respectively, after adjusting for age, sex, body mass index, waist circumference, smoking status, alcohol intake, and physical activity. Higher TyG index precedes and significantly predicts type 2 diabetes among community-dwelling middle aged and elderly lean Koreans.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfTRANSLATIONAL RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBlood Glucose / metabolism*-
dc.subject.MESHCohort Studies-
dc.subject.MESHDiabetes Mellitus, Type 2 / epidemiology-
dc.subject.MESHDiabetes Mellitus, Type 2 / genetics-
dc.subject.MESHDiabetes Mellitus, Type 2 / metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHGenetic Predisposition to Disease*-
dc.subject.MESHHumans-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHTriglycerides / metabolism*-
dc.titleTriglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorByoungjin Park-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorYong-Jae Lee-
dc.identifier.doi10.1016/j.trsl.2020.08.003-
dc.contributor.localIdA01477-
dc.contributor.localIdA02982-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ03229-
dc.identifier.eissn1878-1810-
dc.identifier.pmid32827706-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1931524420302012-
dc.contributor.alternativeNamePark, Byoung Jin-
dc.contributor.affiliatedAuthor박병진-
dc.contributor.affiliatedAuthor이용제-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume228-
dc.citation.startPage42-
dc.citation.endPage51-
dc.identifier.bibliographicCitationTRANSLATIONAL RESEARCH, Vol.228 : 42-51, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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