Cited 64 times in
Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort
DC Field | Value | Language |
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dc.contributor.author | 박병진 | - |
dc.contributor.author | 이용제 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2021-04-29T16:43:26Z | - |
dc.date.available | 2021-04-29T16:43:26Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 1931-5244 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/181982 | - |
dc.description.abstract | The rate of undiagnosed type 2 diabetes tends to increase in lean Koreans, while the triglyceride glucose (TyG) index has been proposed as a surrogate marker of peripheral insulin resistance. We investigated the longitudinal relationship between TyG and incident type 2 diabetes among apparently healthy Korean adults. We assessed 4285 lean adults without diabetes aged 40-69 years from the Korean Genome and Epidemiology Study. Participants were divided into 4 groups according to quartiles of TyG index, calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. We prospectively assessed the hazard ratios (HRs) with 95% confidence intervals (CIs) for incident type 2 diabetes, based on the American Diabetes Association criteria, using multivariate Cox proportional hazards regression models, over 12 years after the baseline survey. During the follow-up period, 631 (14.7%) participants had newly developed type 2 diabetes. The HRs of incident type 2 diabetes in each TyG index quartile were 1.00, 1.63 (95%CI, 1.18-2.24), 2.30 (95%CI, 1.68-3.14), and 3.67 (95%CI, 2.71-4.98), respectively, after adjusting for age, sex, body mass index, waist circumference, smoking status, alcohol intake, and physical activity. Higher TyG index precedes and significantly predicts type 2 diabetes among community-dwelling middle aged and elderly lean Koreans. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | TRANSLATIONAL RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Blood Glucose / metabolism* | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Diabetes Mellitus, Type 2 / epidemiology | - |
dc.subject.MESH | Diabetes Mellitus, Type 2 / genetics | - |
dc.subject.MESH | Diabetes Mellitus, Type 2 / metabolism* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Triglycerides / metabolism* | - |
dc.title | Triglyceride glucose (TyG) index as a predictor of incident type 2 diabetes among nonobese adults: a 12-year longitudinal study of the Korean Genome and Epidemiology Study cohort | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Byoungjin Park | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.identifier.doi | 10.1016/j.trsl.2020.08.003 | - |
dc.contributor.localId | A01477 | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J03229 | - |
dc.identifier.eissn | 1878-1810 | - |
dc.identifier.pmid | 32827706 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1931524420302012 | - |
dc.contributor.alternativeName | Park, Byoung Jin | - |
dc.contributor.affiliatedAuthor | 박병진 | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 228 | - |
dc.citation.startPage | 42 | - |
dc.citation.endPage | 51 | - |
dc.identifier.bibliographicCitation | TRANSLATIONAL RESEARCH, Vol.228 : 42-51, 2021-02 | - |
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