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A cost-effective and sensitive photothermal biosensor for the diagnosis of diabetes based on quantifying the sialic acid content on erythrocytes

Authors
 Kirok Kwon  ;  Sudesna Chakravarty  ;  Kyung-A Hyun  ;  Nam-Ho Bae  ;  Jaewoo Song  ;  Seok Jae Lee  ;  Hyo-Il Jung 
Citation
 SENSORS AND ACTUATORS B-CHEMICAL, Vol.329 : 129259, 2021-02 
Journal Title
SENSORS AND ACTUATORS B-CHEMICAL
ISSN
 0925-4005 
Issue Date
2021-02
Keywords
Photothermal biosensor ; Diabetes ; Sialic acid ; Temperature detector ; Microfluidic
Abstract
Photothermal sensors represent a novel type of probe having potential in the field of clinical diagnostics particularly due to the lack of a tedious sample pre-treatment, a sophisticated equipment and a skilled manpower. Herein, we describe the fabrication of a microfluidic nickel-resistive temperature detector (micro-Ni-RTD) for the selective monitoring of diabetes using a boronate-based sialic acid (SA) receptor. This work represents an improvement made to our previous photothermal sensor designs by reducing the cost by about 100-fold and significantly improving the sensitivity of the device, enabling the detection of sialic acid contents as low as 0.06 μmol/mL, a 4-fold improvement compared to the sensor described our previous study. The average temperature difference between healthy subjects and diabetes patients was found to be 0.181 °C dL/g with micro-Ni-RTD in comparison with 0.043 °C dL/g with our previous platinum-based resistive temperature detector (Pt-RTD) reported previously The enhancement in the discriminatory ability of micro-Ni-RTD for the diabetic clinical samples compared with healthy control can be attributed to the modified surface modification strategy and the incorporation of the microfluidic channels. Thus, micro-Ni-RTD represents a convenient, rapid, reliable, and low-cost biosensor for the clinical monitoring of diabetes patients.
Full Text
https://www.sciencedirect.com/science/article/pii/S0925400520315999
DOI
10.1016/j.snb.2020.129259
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181966
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