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A cost-effective and sensitive photothermal biosensor for the diagnosis of diabetes based on quantifying the sialic acid content on erythrocytes

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dc.contributor.author송재우-
dc.date.accessioned2021-04-29T16:41:40Z-
dc.date.available2021-04-29T16:41:40Z-
dc.date.issued2021-02-
dc.identifier.issn0925-4005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181966-
dc.description.abstractPhotothermal sensors represent a novel type of probe having potential in the field of clinical diagnostics particularly due to the lack of a tedious sample pre-treatment, a sophisticated equipment and a skilled manpower. Herein, we describe the fabrication of a microfluidic nickel-resistive temperature detector (micro-Ni-RTD) for the selective monitoring of diabetes using a boronate-based sialic acid (SA) receptor. This work represents an improvement made to our previous photothermal sensor designs by reducing the cost by about 100-fold and significantly improving the sensitivity of the device, enabling the detection of sialic acid contents as low as 0.06 μmol/mL, a 4-fold improvement compared to the sensor described our previous study. The average temperature difference between healthy subjects and diabetes patients was found to be 0.181 °C dL/g with micro-Ni-RTD in comparison with 0.043 °C dL/g with our previous platinum-based resistive temperature detector (Pt-RTD) reported previously The enhancement in the discriminatory ability of micro-Ni-RTD for the diabetic clinical samples compared with healthy control can be attributed to the modified surface modification strategy and the incorporation of the microfluidic channels. Thus, micro-Ni-RTD represents a convenient, rapid, reliable, and low-cost biosensor for the clinical monitoring of diabetes patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Sequoia-
dc.relation.isPartOfSENSORS AND ACTUATORS B-CHEMICAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleA cost-effective and sensitive photothermal biosensor for the diagnosis of diabetes based on quantifying the sialic acid content on erythrocytes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Laboratory Medicine (진단검사의학교실)-
dc.contributor.googleauthorKirok Kwon-
dc.contributor.googleauthorSudesna Chakravarty-
dc.contributor.googleauthorKyung-A Hyun-
dc.contributor.googleauthorNam-Ho Bae-
dc.contributor.googleauthorJaewoo Song-
dc.contributor.googleauthorSeok Jae Lee-
dc.contributor.googleauthorHyo-Il Jung-
dc.identifier.doi10.1016/j.snb.2020.129259-
dc.contributor.localIdA02054-
dc.relation.journalcodeJ02654-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0925400520315999-
dc.subject.keywordPhotothermal biosensor-
dc.subject.keywordDiabetes-
dc.subject.keywordSialic acid-
dc.subject.keywordTemperature detector-
dc.subject.keywordMicrofluidic-
dc.contributor.alternativeNameSong, Jae Woo-
dc.contributor.affiliatedAuthor송재우-
dc.citation.volume329-
dc.citation.startPage129259-
dc.identifier.bibliographicCitationSENSORS AND ACTUATORS B-CHEMICAL, Vol.329 : 129259, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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