Cited 5 times in
A cost-effective and sensitive photothermal biosensor for the diagnosis of diabetes based on quantifying the sialic acid content on erythrocytes
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송재우 | - |
dc.date.accessioned | 2021-04-29T16:41:40Z | - |
dc.date.available | 2021-04-29T16:41:40Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 0925-4005 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/181966 | - |
dc.description.abstract | Photothermal sensors represent a novel type of probe having potential in the field of clinical diagnostics particularly due to the lack of a tedious sample pre-treatment, a sophisticated equipment and a skilled manpower. Herein, we describe the fabrication of a microfluidic nickel-resistive temperature detector (micro-Ni-RTD) for the selective monitoring of diabetes using a boronate-based sialic acid (SA) receptor. This work represents an improvement made to our previous photothermal sensor designs by reducing the cost by about 100-fold and significantly improving the sensitivity of the device, enabling the detection of sialic acid contents as low as 0.06 μmol/mL, a 4-fold improvement compared to the sensor described our previous study. The average temperature difference between healthy subjects and diabetes patients was found to be 0.181 °C dL/g with micro-Ni-RTD in comparison with 0.043 °C dL/g with our previous platinum-based resistive temperature detector (Pt-RTD) reported previously The enhancement in the discriminatory ability of micro-Ni-RTD for the diabetic clinical samples compared with healthy control can be attributed to the modified surface modification strategy and the incorporation of the microfluidic channels. Thus, micro-Ni-RTD represents a convenient, rapid, reliable, and low-cost biosensor for the clinical monitoring of diabetes patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Sequoia | - |
dc.relation.isPartOf | SENSORS AND ACTUATORS B-CHEMICAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | A cost-effective and sensitive photothermal biosensor for the diagnosis of diabetes based on quantifying the sialic acid content on erythrocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Kirok Kwon | - |
dc.contributor.googleauthor | Sudesna Chakravarty | - |
dc.contributor.googleauthor | Kyung-A Hyun | - |
dc.contributor.googleauthor | Nam-Ho Bae | - |
dc.contributor.googleauthor | Jaewoo Song | - |
dc.contributor.googleauthor | Seok Jae Lee | - |
dc.contributor.googleauthor | Hyo-Il Jung | - |
dc.identifier.doi | 10.1016/j.snb.2020.129259 | - |
dc.contributor.localId | A02054 | - |
dc.relation.journalcode | J02654 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0925400520315999 | - |
dc.subject.keyword | Photothermal biosensor | - |
dc.subject.keyword | Diabetes | - |
dc.subject.keyword | Sialic acid | - |
dc.subject.keyword | Temperature detector | - |
dc.subject.keyword | Microfluidic | - |
dc.contributor.alternativeName | Song, Jae Woo | - |
dc.contributor.affiliatedAuthor | 송재우 | - |
dc.citation.volume | 329 | - |
dc.citation.startPage | 129259 | - |
dc.identifier.bibliographicCitation | SENSORS AND ACTUATORS B-CHEMICAL, Vol.329 : 129259, 2021-02 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.