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Serum granzyme B is associated with otorhinolaryngological; pulmonary; and renal involvement of antineutrophil cytoplasmic antibody-associated vasculitis

 Taejun Yoon  ;  Juyoung Yoo  ;  Sung Soo Ahn  ;  Jason Jungsik Song  ;  Yong-Beom Park  ;  Sang-Won Lee 
 JOURNAL OF INVESTIGATIVE MEDICINE, Vol.69(1) : 91-95, 2021-01 
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We investigated whether serum granzyme B (GrB) can reflect the inflammatory burden such as cross-sectional disease activity and organ-specific involvement in immunosuppressive drug-naïve patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Seventy-eight immunosuppressive drug-naïve patients with AAV were included in this study. At the time of the first classification; whole blood was obtained from each patient and sera was immediately isolated and stored at - 80℃. On the day of the blood sampling; we performed routine laboratory tests including antineutrophil cytoplasmic antibody tests and collected both clinical and laboratory data. AAV-specific indices included Birmingham Vasculitis Activity Score (BVAS) and Five-Factor Score (FFS). The median age of patients with AAV was 62 years and 26 patients were men. Serum GrB was not associated with the cross-sectional BVAS; however; patients with serum GrB positivity exhibited higher frequencies of otorhinolaryngological manifestation than those without (p=0.037). When serum GrB levels were compared after dividing the patients into two groups based on the presence of organ-specific involvement; patients with pulmonary involvement exhibited a significantly higher serum GrB than those without (p=0.042). On the other hand; patients with renal involvement showed a significantly lower serum GrB than those without (p=0.023). In addition; serum GrB was inversely correlated with the cross-sectional FFS (r=-0.249; p=0.028). Even though serum GrB could not reflect the inflammatory burden of AAV; serum GrB was associated with otorhinolaryngological; pulmonary; and renal involvement in immunosuppressive drug-naïve patients with AAV.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Beom(박용범)
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-9002-9880
Yoo, Juyoung(유주영) ORCID logo https://orcid.org/0000-0001-8882-1695
Lee, Sang-Won(이상원) ORCID logo https://orcid.org/0000-0002-8038-3341
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