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p16 methylation is a potential predictive marker for abemaciclib sensitivity in gastric cancer

DC Field Value Language
dc.contributor.authorBae, Hyun Joo-
dc.contributor.authorKang, Sun Kyoung-
dc.contributor.authorKwon, Woo Sun-
dc.contributor.authorJeong, Inhye-
dc.contributor.authorPark, Sejung-
dc.contributor.authorKim, Tae Soo-
dc.contributor.authorKim, Kyoo Hyun-
dc.contributor.authorKim, Hyunki-
dc.contributor.authorJeong, Hei-Cheul-
dc.contributor.authorChung, Hyun Cheol-
dc.contributor.authorRha, Sun Young-
dc.date.accessioned2021-03-31T02:15:29Z-
dc.date.available2021-03-31T02:15:29Z-
dc.date.created2021-02-22-
dc.date.issued2021-01-
dc.identifier.issn0006-2952-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181875-
dc.description.abstractCell cycle control is often disrupted in gastric cancer (GC), making it an attractive therapeutic target. Abemaciclib is a specific CDK4/6 inhibitor that has been shown to improve treatment efficacy in hormone receptor positive advanced breast cancer; however, its potential therapeutic value and predictive markers have not yet been revealed in GC. In this study, we investigated the efficacy of abemaciclib using preclinical GC models representing defined molecular subtypes from The Cancer Genome Atlas. In these 49 GC cell lines, Epstein-Barr virus (EBV) and high microsatellite instability (MSI-H)-type cell lines were p16 methylated and sensitive to abemaciclib; further, genomically stable (GS), and chromosomal instability (CIN)-type cell lines with p16 methylation and intact Rb were also found to be responsive. In addition, we found that GC patients with p16 methylation often displayed a poor prognosis. Collectively, these data provide a foundation for clinical trials to assess the therapeutic efficacy of abemaciclib in GC and suggest that p16 methylation could be used as a predictive marker to identify patients with GC who may benefit from abemaciclib-based therapies.-
dc.language영어-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.relation.isPartOfBIOCHEMICAL PHARMACOLOGY-
dc.titlep16 methylation is a potential predictive marker for abemaciclib sensitivity in gastric cancer-
dc.typeArticle-
dc.contributor.googleauthorBae, Hyun Joo-
dc.contributor.googleauthorKang, Sun Kyoung-
dc.contributor.googleauthorKwon, Woo Sun-
dc.contributor.googleauthorJeong, Inhye-
dc.contributor.googleauthorPark, Sejung-
dc.contributor.googleauthorKim, Tae Soo-
dc.contributor.googleauthorKim, Kyoo Hyun-
dc.contributor.googleauthorKim, Hyunki-
dc.contributor.googleauthorJeong, Hei-Cheul-
dc.contributor.googleauthorChung, Hyun Cheol-
dc.contributor.googleauthorRha, Sun Young-
dc.identifier.doi10.1016/j.bcp.2020.114320-
dc.relation.journalcodeJ00283-
dc.identifier.eissn1873-2968-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0006295220305566-
dc.subject.keywordAbemaciclib-
dc.subject.keywordGastric cancer-
dc.subject.keywordP16-
dc.subject.keywordMethylation-
dc.subject.keywordCell cycle-
dc.contributor.affiliatedAuthorBae, Hyun Joo-
dc.contributor.affiliatedAuthorKwon, Woo Sun-
dc.contributor.affiliatedAuthorJeong, Inhye-
dc.contributor.affiliatedAuthorKim, Hyunki-
dc.contributor.affiliatedAuthorJeong, Hei-Cheul-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.identifier.scopusid2-s2.0-85095956174-
dc.identifier.wosid000604266500006-
dc.citation.titleBIOCHEMICAL PHARMACOLOGY-
dc.citation.volume183-
dc.citation.startPage114320-
dc.identifier.bibliographicCitationBIOCHEMICAL PHARMACOLOGY, Vol.183 : 114320, 2021-01-
dc.identifier.rimsid67591-
dc.type.rimsART-
dc.description.journalClass1-
dc.description.journalClass1-
dc.subject.keywordAuthorAbemaciclib-
dc.subject.keywordAuthorGastric cancer-
dc.subject.keywordAuthorP16-
dc.subject.keywordAuthorMethylation-
dc.subject.keywordAuthorCell cycle-
dc.subject.keywordPlusINHIBITOR-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusADENOCARCINOMA-
dc.subject.keywordPlusRAMUCIRUMAB-
dc.subject.keywordPlusPACLITAXEL-
dc.subject.keywordPlusRIBOCICLIB-
dc.subject.keywordPlusCDK4-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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