Cited 35 times in
The triglyceride-glucose index predicts ischemic heart disease risk in Koreans: a prospective study using National Health Insurance Service data
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박병진 | - |
dc.contributor.author | 이용제 | - |
dc.contributor.author | 이혜선 | - |
dc.contributor.author | 정동혁 | - |
dc.date.accessioned | 2021-01-19T08:19:20Z | - |
dc.date.available | 2021-01-19T08:19:20Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/181562 | - |
dc.description.abstract | Background: Ischemic heart disease (IHD) without diabetes is considered an important challenge to human health and is associated with a poor prognosis, as well as a lack of health awareness. We prospectively investigated the relationship between the triglyceride-glucose (TyG) index, a surrogate marker of early insulin resistance, and incident IHD risk in a large cohort of nondiabetic Korean adults using National Health Insurance Service data. Methods: We assessed 16,455 participants (8426 men and 8029 women) without diabetes using data from a health risk assessment study (HERAS) and Korea Health Insurance Review and Assessment (HIRA) data. The participants were divided into four groups according to TyG index quartiles, calculated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2]. We prospectively assessed hazard ratios (HRs) with 95% confidence intervals (CIs) for IHD using multivariate Cox proportional-hazards regression models over a 50-month period that followed the baseline survey. Results: During the follow-up period, 322 (2.0%) participants developed IHD. HRs of IHD for TyG index quartiles 2-4 were 1.61 (95% CI 1.05-2.48), 1.85 (95% CI 1.21-2.81), and 2.29 (95% CI 1.50-3.51), respectively, after adjusting for age, sex, body mass index, smoking status, alcohol intake, and physical activity. Conclusions: A higher TyG index precedes and significantly predicts future IHD among nondiabetic Koreans. Accordingly, the TyG index may be a useful measure in assessing cardiovascular risk for nondiabetic adults in the preclinical stage. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The triglyceride-glucose index predicts ischemic heart disease risk in Koreans: a prospective study using National Health Insurance Service data | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Byoungjin Park | - |
dc.contributor.googleauthor | Yong-Jae Lee | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Dong-Hyuk Jung | - |
dc.identifier.doi | 10.1186/s12933-020-01186-2 | - |
dc.contributor.localId | A01477 | - |
dc.contributor.localId | A02982 | - |
dc.contributor.localId | A03312 | - |
dc.contributor.localId | A03595 | - |
dc.relation.journalcode | J00460 | - |
dc.identifier.eissn | 1475-2840 | - |
dc.identifier.pmid | 33302952 | - |
dc.subject.keyword | Early insulin resistance | - |
dc.subject.keyword | Incident ischemic heart disease | - |
dc.subject.keyword | Prospective cohort study | - |
dc.subject.keyword | Triglyceride glucose index | - |
dc.contributor.alternativeName | Park, Byoung Jin | - |
dc.contributor.affiliatedAuthor | 박병진 | - |
dc.contributor.affiliatedAuthor | 이용제 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.contributor.affiliatedAuthor | 정동혁 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 210 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, Vol.19(1) : 210, 2020-12 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.