0 47

Cited 0 times in

Clinicopathological characteristics of intrahepatic cholangiocarcinoma according to gross morphologic type: cholangiolocellular differentiation traits and inflammation- and proliferation-phenotypes

DC FieldValueLanguage
dc.contributor.author남지해-
dc.contributor.author박영년-
dc.contributor.author유정은-
dc.contributor.author이형진-
dc.contributor.author한대훈-
dc.date.accessioned2021-01-19T08:14:06Z-
dc.date.available2021-01-19T08:14:06Z-
dc.date.issued2020-06-
dc.identifier.issn1365-182X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181521-
dc.description.abstractBackground: Intrahepatic cholangiocarcinoma (iCCA) is subclassified into mass-forming (MF), periductal-infiltrative (PI), and mixed types grossly; however, their clinicopathological significance remains controversial. Methods: Clinicopathological characteristics of iCCA gross types were analysed according to histopathological type (small-duct, large-duct, indeterminate) or cholangiolocellular differentiation trait (CDT) in 108 iCCAs. The expression levels of inflammation-marker (CRP, FGB) and proliferation-marker (phospho-ERK1/2, Ki-67) were evaluated by immunohistochemistry. Results: There were 87 MF, 8 PI, and 13 mixed-gross type. Small-duct-type (39, 44.8%) and CDT (19, 21.8%) were found only in MF-gross type. The inflammation-marker expression was higher in MF-type than in PI- and mixed-gross types (P = 0.023). It was high in small-duct-type, middle in indeterminate-type, and low in large-duct-type (P = 0.015), and iCCAs with CDT showed higher inflammation-marker expression compared to those without (P < 0.001). Proliferation-marker expression did not differ according to gross type; however it was lower in iCCA with CDT compared to those without (P = 0.004). Subgrouping of the gross type according to histopathological type or CDT revealed that MF-type with small-duct-type or CDT had better overall survival compared to the others (P < 0.05). Conclusion: MF-type iCCA is more heterogeneous than other gross types. High inflammation-marker/low proliferation-marker expression in MF-type with CDT or small-duct-type may be related to a good outcome.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfHPB-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinicopathological characteristics of intrahepatic cholangiocarcinoma according to gross morphologic type: cholangiolocellular differentiation traits and inflammation- and proliferation-phenotypes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학교실)-
dc.contributor.googleauthorTaek Chung-
dc.contributor.googleauthorHyungjin Rhee-
dc.contributor.googleauthorJi Hae Nahm-
dc.contributor.googleauthorYoungsic Jeon-
dc.contributor.googleauthorJeong Eun Yoo-
dc.contributor.googleauthorYoung-Joo Kim-
dc.contributor.googleauthorDai Hoon Han-
dc.contributor.googleauthorYoung Nyun Park-
dc.identifier.doi10.1016/j.hpb.2019.10.009-
dc.contributor.localIdA05120-
dc.contributor.localIdA01563-
dc.contributor.localIdA01563-
dc.contributor.localIdA02504-
dc.contributor.localIdA02504-
dc.contributor.localIdA05171-
dc.contributor.localIdA05171-
dc.contributor.localIdA04273-
dc.contributor.localIdA04273-
dc.relation.journalcodeJ03345-
dc.identifier.eissn1477-2574-
dc.identifier.pmid31735647-
dc.identifier.urlhttps://www.clinicalkey.com/#!/content/playContent/1-s2.0-S1365182X19307403-
dc.contributor.alternativeNameNahm, Ji Hae-
dc.contributor.affiliatedAuthor남지해-
dc.contributor.affiliatedAuthor박영년-
dc.contributor.affiliatedAuthor박영년-
dc.contributor.affiliatedAuthor유정은-
dc.contributor.affiliatedAuthor유정은-
dc.contributor.affiliatedAuthor이형진-
dc.contributor.affiliatedAuthor이형진-
dc.contributor.affiliatedAuthor한대훈-
dc.contributor.affiliatedAuthor한대훈-
dc.citation.volume22-
dc.citation.number6-
dc.citation.startPage864-
dc.citation.endPage873-
dc.identifier.bibliographicCitationHPB, Vol.22(6) : 864-873, 2020-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.