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Minimal parkinsonism in the elderly is associated with striatal dopamine loss and pontine structural damage

Authors
 Seok Jong Chung  ;  Han Soo Yoo  ;  Yang Hyun Lee  ;  Young H Sohn  ;  Byoung Seok Ye  ;  Jungho Cha  ;  Phil Hyu Lee 
Citation
 PARKINSONISM & RELATED DISORDERS, Vol.81 : 140-143, 2020-12 
Journal Title
 PARKINSONISM & RELATED DISORDERS 
ISSN
 1353-8020 
Issue Date
2020-12
Keywords
Brainstem ; Dopamine transporter ; Parkinsonism ; Substantia nigra
Abstract
Introduction: To investigate whether neurodegeneration underlying Parkinson's disease (PD) accounts for a substantial proportion of cases of minimal parkinsonism in the elderly. Methods: We recruited 48 consecutive subjects with minimal parkinsonism who visited the clinic with cognitive complaints. All subjects did not show findings compatible with PD on 18F-FP-CIT PET scans, and had no evidence of other neurodegenerative disorders. Striatal dopamine transporter (DAT) availability was quantified, and mean diffusivity (MD) values in the pons were calculated to characterize structural damage using diffusion tensor imaging. Additionally, 35 patients with PD and 21 healthy controls were included as reference groups. Results: Individuals with minimal parkinsonism (mean age, 73.23 ± 7.03 years) exhibited mild decrease in DAT availability in the posterior putamen, which was at a level between that of healthy controls and patients with PD. DAT availability in the caudate and anterior putamen was also mildly decreased in the minimal parkinsonism group. Individuals with minimal parkinsonism also tended to have higher MD values in the pons compared to healthy controls. Conclusions: Our results suggest that a substantial proportion of minimal parkinsonism is associated with nigrostriatal dopamine depletion and pontine structural damage, which may be related to the disease process of prodromal PD.
Full Text
https://www.sciencedirect.com/science/article/pii/S1353802020308312
DOI
10.1016/j.parkreldis.2020.10.038
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Yang Hyun(이양현)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181469
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