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Association of serum vitamin D with frailty in older Korean adults

 Jinhee Kim  ;  Yunhwan Lee  ;  Chang Won Won  ;  Seunghee Kye  ;  Jee-Seon Shim 
 MATURITAS, Vol.134 : 15-20, 2020-04 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Aging / blood ; Cohort Studies ; Cross-Sectional Studies ; Female ; Frail Elderly* ; Frailty / blood* ; Humans ; Male ; Prevalence ; Republic of Korea / epidemiology ; Vitamin D / blood* ; Vitamin D Deficiency / blood*
Community-dwelling older persons ; Frailty ; Vitamin D
Objectives: The association between serum levels of vitamin D and frailty in older Korean adults was examined. Study design: Cross-sectional study. Older people living in the community across 10 study centers throughout South Korea. The baseline data (2016-2017) of 2872 participants aged 70-84 years in the Korean Frailty and Aging Cohort Study were evaluated. Main outcome measures: Serum vitamin D level was assessed with an electro-chemiluminescence immunoassay. Frailty was defined using Fried's frailty index. A multinomial logistic regression analysis was used to examine the association between serum levels of vitamin D and frailty. Results: The percentages of those with serum vitamin D levels of <25 nmol/L, 25-49 nmol/L, 50-74 nmol/L, and ≥75 nmol/L were 4.1 %, 37.0 %, 37.8 %, and 21.0 %, respectively. The prevalence of frailty was 9.7 %. Those with lower serum vitamin D levels, compared with ≥75 nmol/L, tended to have higher odds of being frail than being non-frail (OR: 1.58, 95 % CI: 1.05-2.39 for 50-74 nmol/L; OR: 1.49, 95 % CI: 0.98-2.26 for 25-49 nmol/L; OR: 1.37, 95 % CI: 0.65-2.88 for <25 nmol/L). Among the components of frailty, low grip strength was significantly associated with lower serum levels of vitamin D. Conclusions: Low serum levels of vitamin D are associated with an increased likelihood of frailty in community-dwelling older adults, suggesting a potentially protective role of vitamin D against frailty.
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1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Shim, Jee Seon(심지선) ORCID logo https://orcid.org/0000-0002-8671-3153
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