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Association of serum vitamin D with frailty in older Korean adults

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dc.contributor.author심지선-
dc.date.accessioned2021-01-19T08:00:36Z-
dc.date.available2021-01-19T08:00:36Z-
dc.date.issued2020-04-
dc.identifier.issn0378-5122-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181422-
dc.description.abstractObjectives: The association between serum levels of vitamin D and frailty in older Korean adults was examined. Study design: Cross-sectional study. Older people living in the community across 10 study centers throughout South Korea. The baseline data (2016-2017) of 2872 participants aged 70-84 years in the Korean Frailty and Aging Cohort Study were evaluated. Main outcome measures: Serum vitamin D level was assessed with an electro-chemiluminescence immunoassay. Frailty was defined using Fried's frailty index. A multinomial logistic regression analysis was used to examine the association between serum levels of vitamin D and frailty. Results: The percentages of those with serum vitamin D levels of <25 nmol/L, 25-49 nmol/L, 50-74 nmol/L, and ≥75 nmol/L were 4.1 %, 37.0 %, 37.8 %, and 21.0 %, respectively. The prevalence of frailty was 9.7 %. Those with lower serum vitamin D levels, compared with ≥75 nmol/L, tended to have higher odds of being frail than being non-frail (OR: 1.58, 95 % CI: 1.05-2.39 for 50-74 nmol/L; OR: 1.49, 95 % CI: 0.98-2.26 for 25-49 nmol/L; OR: 1.37, 95 % CI: 0.65-2.88 for <25 nmol/L). Among the components of frailty, low grip strength was significantly associated with lower serum levels of vitamin D. Conclusions: Low serum levels of vitamin D are associated with an increased likelihood of frailty in community-dwelling older adults, suggesting a potentially protective role of vitamin D against frailty.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier/North Holland Biomedical Press-
dc.relation.isPartOfMATURITAS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAging / blood-
dc.subject.MESHCohort Studies-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHFemale-
dc.subject.MESHFrail Elderly*-
dc.subject.MESHFrailty / blood*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHPrevalence-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHVitamin D / blood*-
dc.subject.MESHVitamin D Deficiency / blood*-
dc.titleAssociation of serum vitamin D with frailty in older Korean adults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine and Public Health (예방의학교실)-
dc.contributor.googleauthorJinhee Kim-
dc.contributor.googleauthorYunhwan Lee-
dc.contributor.googleauthorChang Won Won-
dc.contributor.googleauthorSeunghee Kye-
dc.contributor.googleauthorJee-Seon Shim-
dc.identifier.doi10.1016/j.maturitas.2020.01.008-
dc.contributor.localIdA02212-
dc.relation.journalcodeJ02190-
dc.identifier.eissn1873-4111-
dc.identifier.pmid32143771-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0378512219306413-
dc.subject.keywordCommunity-dwelling older persons-
dc.subject.keywordFrailty-
dc.subject.keywordVitamin D-
dc.contributor.alternativeNameShim, Jee Seon-
dc.contributor.affiliatedAuthor심지선-
dc.citation.volume134-
dc.citation.startPage15-
dc.citation.endPage20-
dc.identifier.bibliographicCitationMATURITAS, Vol.134 : 15-20, 2020-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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