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The preclinical amyloid sensitive composite to determine subtle cognitive differences in preclinical Alzheimer's disease

 Alice Hahn  ;  Young Ju Kim  ;  Hee Jin Kim  ;  Hyemin Jang  ;  Hanna Cho  ;  Seong Hye Choi  ;  Byeong C Kim  ;  Kyung Won Park  ;  Duk L Na  ;  Juhee Chin  ;  Sang Won Seo 
 SCIENTIFIC REPORTS, Vol.10(1) : 13583, 2020-08 
Journal Title
Issue Date
Aged ; Aged, 80 and over ; Alzheimer Disease / diagnosis ; Alzheimer Disease / metabolism ; Alzheimer Disease / physiopathology* ; Amyloid / metabolism* ; Apolipoprotein E4 / metabolism ; Cognition / physiology* ; Executive Function / physiology* ; Female ; Humans ; Male ; Memory / physiology* ; Middle Aged ; Positron-Emission Tomography / methods ; ROC Curve ; Reproducibility of Results
Recently, the focus of Alzheimer's disease (AD) research has shifted from the clinical stage to the preclinical stage. We, therefore, aimed to develop a cognitive composite score that can detect the subtle cognitive differences between the amyloid positive (Aβ+) and negative (Aβ-) status in cognitively normal (CN) participants. A total of 423 CN participants with Aβ positron emission tomography images were recruited. The multiple-indicators multiple-causes model found the latent mean difference between the Aβ+ and Aβ- groups in the domains of verbal memory, visual memory, and executive functions. The multivariate analysis of covariance (MANCOVA) showed that the Aβ+ group performed worse in tests related to the verbal and visual delayed recall, semantic verbal fluency, and inhibition of cognitive inference within the three cognitive domains. The Preclinical Amyloid Sensitive Composite (PASC) model we developed using the result of MANCOVA and the MMSE presented a good fit with the data. The accuracy of the PASC score when applied with age, sex, education, and APOE ε4 for distinguishing between Aβ+ and Aβ- was adequate (AUC = 0.764; 95% CI = 0.667-0.860) in the external validation set (N = 179). We conclude that the PASC can eventually contribute to facilitating more prevention trials in preclinical AD.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
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