18 43

Cited 0 times in

The preclinical amyloid sensitive composite to determine subtle cognitive differences in preclinical Alzheimer's disease

DC FieldValueLanguage
dc.contributor.author조한나-
dc.date.accessioned2021-01-19T07:51:42Z-
dc.date.available2021-01-19T07:51:42Z-
dc.date.issued2020-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181353-
dc.description.abstractRecently, the focus of Alzheimer's disease (AD) research has shifted from the clinical stage to the preclinical stage. We, therefore, aimed to develop a cognitive composite score that can detect the subtle cognitive differences between the amyloid positive (Aβ+) and negative (Aβ-) status in cognitively normal (CN) participants. A total of 423 CN participants with Aβ positron emission tomography images were recruited. The multiple-indicators multiple-causes model found the latent mean difference between the Aβ+ and Aβ- groups in the domains of verbal memory, visual memory, and executive functions. The multivariate analysis of covariance (MANCOVA) showed that the Aβ+ group performed worse in tests related to the verbal and visual delayed recall, semantic verbal fluency, and inhibition of cognitive inference within the three cognitive domains. The Preclinical Amyloid Sensitive Composite (PASC) model we developed using the result of MANCOVA and the MMSE presented a good fit with the data. The accuracy of the PASC score when applied with age, sex, education, and APOE ε4 for distinguishing between Aβ+ and Aβ- was adequate (AUC = 0.764; 95% CI = 0.667-0.860) in the external validation set (N = 179). We conclude that the PASC can eventually contribute to facilitating more prevention trials in preclinical AD.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAlzheimer Disease / diagnosis-
dc.subject.MESHAlzheimer Disease / metabolism-
dc.subject.MESHAlzheimer Disease / physiopathology*-
dc.subject.MESHAmyloid / metabolism*-
dc.subject.MESHApolipoprotein E4 / metabolism-
dc.subject.MESHCognition / physiology*-
dc.subject.MESHExecutive Function / physiology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMemory / physiology*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPositron-Emission Tomography / methods-
dc.subject.MESHROC Curve-
dc.subject.MESHReproducibility of Results-
dc.titleThe preclinical amyloid sensitive composite to determine subtle cognitive differences in preclinical Alzheimer's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorAlice Hahn-
dc.contributor.googleauthorYoung Ju Kim-
dc.contributor.googleauthorHee Jin Kim-
dc.contributor.googleauthorHyemin Jang-
dc.contributor.googleauthorHanna Cho-
dc.contributor.googleauthorSeong Hye Choi-
dc.contributor.googleauthorByeong C Kim-
dc.contributor.googleauthorKyung Won Park-
dc.contributor.googleauthorDuk L Na-
dc.contributor.googleauthorJuhee Chin-
dc.contributor.googleauthorSang Won Seo-
dc.identifier.doi10.1038/s41598-020-70386-3-
dc.contributor.localIdA03920-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid32788669-
dc.contributor.alternativeNameCho, Hanna-
dc.contributor.affiliatedAuthor조한나-
dc.citation.volume10-
dc.citation.number1-
dc.citation.startPage13583-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.10(1) : 13583, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.