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MRI Ancillary Features for LI-RADS Category 3 and 4 Observations: Improved Categorization to Indicate the Risk of Hepatic Malignancy

DC FieldValueLanguage
dc.contributor.author김명진-
dc.contributor.author김승업-
dc.contributor.author김연윤-
dc.contributor.author박미숙-
dc.contributor.author이명지-
dc.contributor.author정용은-
dc.contributor.author최진영-
dc.date.accessioned2021-01-19T07:42:59Z-
dc.date.available2021-01-19T07:42:59Z-
dc.date.issued2020-12-
dc.identifier.issn0361-803X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181303-
dc.description.abstractOBJECTIVE. The purpose of this study was to investigate whether ancillary features can help stratify malignancy risk in Liver Imaging Reporting and Data System (LI-RADS) category 3 (LR-3) and 4 (LR-4) observations. MATERIALS AND METHODS. This retrospective longitudinal study included 106 LR-3 or LR-4 observations on gadolinium-enhanced MRI obtained from January 2014 to December 2015 in 80 patients who were treatment naïve and at risk (mean age, 58.0 ± 10.7 [SD] years; 60 men). The presence of major and ancillary features, the category determined using only major features, and the final category adjusted by the application of ancillary features were retrospectively analyzed. MRI features were compared using generalized estimating equations, and cumulative incidence curves for malignancy were compared using log-rank tests with a resampling extension. RESULTS. At 6-month follow-up, the cumulative incidence of observations initially categorized as LR-4, observations upgraded to LR-4, observations initially categorized as LR-3, and observations downgraded to LR-3 were 62.5%, 29.7%, 6.2%, and 0%, respectively. The cumulative incidence of malignancy did not differ between observations categorized by major feature as LR-3 and LR-4 (p = 0.12), but was higher in final observations categorized as LR-4 than in those categorized as LR-3 (p < 0.001). Among observations categorized by major feature as LR-3, the cumulative incidence of malignancy was higher in observations upgraded to LR-4 than in observations that were initially graded as LR-3 (p = 0.03), which showed differences in the frequency of restricted diffusion and mild-to-moderate T2-weighted hyperintensity (p < 0.001 for both). CONCLUSION. Final categories determined with ancillary features, instead of categories determined by major features only, can help indicate malignancy risk in LR-3 and LR-4 observations on MRI.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringfield, Ill., Thomas-
dc.relation.isPartOfAMERICAN JOURNAL OF ROENTGENOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleMRI Ancillary Features for LI-RADS Category 3 and 4 Observations: Improved Categorization to Indicate the Risk of Hepatic Malignancy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorYeun-Yoon Kim-
dc.contributor.googleauthorJin-Young Choi-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorMyeongjee Lee-
dc.contributor.googleauthorMi-Suk Park-
dc.contributor.googleauthorYong Eun Chung-
dc.contributor.googleauthorMyeong-Jin Kim-
dc.identifier.doi10.2214/AJR.20.22802-
dc.contributor.localIdA00426-
dc.contributor.localIdA00654-
dc.contributor.localIdA00654-
dc.contributor.localIdA04902-
dc.contributor.localIdA04902-
dc.contributor.localIdA01463-
dc.contributor.localIdA01463-
dc.contributor.localIdA05996-
dc.contributor.localIdA05996-
dc.contributor.localIdA03662-
dc.contributor.localIdA03662-
dc.contributor.localIdA04200-
dc.contributor.localIdA04200-
dc.relation.journalcodeJ00116-
dc.identifier.eissn1546-3141-
dc.identifier.pmid33052732-
dc.identifier.urlhttps://www.ajronline.org/doi/10.2214/AJR.20.22802-
dc.subject.keywordMRI-
dc.subject.keywordfollow-up studies-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordliver neoplasms-
dc.subject.keywordrisk assessment-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.affiliatedAuthor김명진-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor김승업-
dc.contributor.affiliatedAuthor김연윤-
dc.contributor.affiliatedAuthor김연윤-
dc.contributor.affiliatedAuthor박미숙-
dc.contributor.affiliatedAuthor박미숙-
dc.contributor.affiliatedAuthor이명지-
dc.contributor.affiliatedAuthor이명지-
dc.contributor.affiliatedAuthor정용은-
dc.contributor.affiliatedAuthor정용은-
dc.contributor.affiliatedAuthor최진영-
dc.contributor.affiliatedAuthor최진영-
dc.citation.volume215-
dc.citation.number6-
dc.citation.startPage1354-
dc.citation.endPage1362-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF ROENTGENOLOGY, Vol.215(6) : 1354-1362, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers

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