137 415

Cited 1 times in

Maladaptive Alterations of Defensive Response Following Developmental Complex Stress in Rats

Authors
 Junhyung Kim  ;  Minkyung Park  ;  Chiheon Lee  ;  Jung Jin Ha  ;  June-Seek Choi  ;  Chul Hoon Kim  ;  Jeong-Ho Seok 
Citation
 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, Vol.18(3) : 412-422, 2020-08 
Journal Title
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
ISSN
 1738-1088 
Issue Date
2020-08
Keywords
Animal model ; Anxiety ; Freezing reaction ; Trauma ; Vocalization ; animal ; cataleptic
Abstract
Objective: Despite the etiological significance of complex developmental trauma in adult personality disorders and treatment-resistant depression, neurobiological studies have been rare due to the lack of useful animal models. As a first step, we devised an animal model to investigate the effects of multiple trauma-like stress during different developmental periods.

Methods: Twenty-one male Sprague-Dawley rats were classified into 3 groups based on the stress protocol: fear conditioning control (FCC, n = 6), complex stress (ComS, n = 9), and control (n = 6). While the ComS experienced three types of stress (maternal separation, juvenile isolation, electric foot shock), the FCC only experienced an electric foot shock stress and the control never experienced any. We compared fear responses at postnatal day (PND) 29 and PND 56 through freezing time per episode (FTpE), total freezing time (TFT), total freezing episodes (TFE), and ultrasonic vocalization (USV).

Results: ComS showed the longest FTpE in the conditioned fear response test. ComS and FCC exhibited the longer TFT and these two groups only displayed USV. ComS show difference TFE between PND 29 and PND 56.

Conclusion: The results of this investigation show that complex stress may affect not quantity of fear response but characteristics of fear response. Longer FTpE may be associated with tonic immobility which could be considered as a failed self-protective reaction and might be analogous to a sign of inappropriate coping strategy and self-dysregulation in complex trauma patients.
Files in This Item:
T202005315.pdf Download
DOI
10.9758/cpn.2020.18.3.412
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chul Hoon(김철훈) ORCID logo https://orcid.org/0000-0002-7360-429X
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180789
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links