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Bio-Interactive Zwitterionic Dental Biomaterials for Improving Biofilm Resistance: Characteristics and Applications

Authors
 Utkarsh Mangal  ;  Jae-Sung Kwon  ;  Sung-Hwan Choi 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(23) : E9087, 2020-11 
Journal Title
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 
Issue Date
2020-11
Keywords
2-methacryloyloxyethyl phosphorylcholine ; anti-biofouling ; biofilm ; carboxybetaine methacrylate ; sulfobetaine methacrylate ; zwitterionic polymers
Abstract
Biofilms are formed on surfaces inside the oral cavity covered by the acquired pellicle and develop into a complex, dynamic, microbial environment. Oral biofilm is a causative factor of dental and periodontal diseases. Accordingly, novel materials that can resist biofilm formation have attracted significant attention. Zwitterionic polymers (ZPs) have unique features that resist protein adhesion and prevent biofilm formation while maintaining biocompatibility. Recent literature has reflected a rapid increase in the application of ZPs as coatings and additives with promising outcomes. In this review, we briefly introduce ZPs and their mechanism of antifouling action, properties of human oral biofilms, and present trends in anti-biofouling, zwitterionic, dental materials. Furthermore, we highlight the existing challenges in the standardization of biofilm research and the future of antifouling, zwitterated, dental materials.
Files in This Item:
T202005224.pdf Download
DOI
10.3390/ijms21239087
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180766
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