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Adverse Initial CT Findings Associated with Poor Prognosis of Coronavirus Disease

DC Field Value Language
dc.contributor.author서영주-
dc.date.accessioned2020-12-11T07:57:40Z-
dc.date.available2020-12-11T07:57:40Z-
dc.date.issued2020-08-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180726-
dc.description.abstractBackground: The predictors of poor prognosis in patients with coronavirus disease 2019 (COVID-19) using computed tomography (CT) have not been investigated in a large cohort. Therefore, the purpose of this study was to investigate the adverse initial CT features to predict poor prognosis in COVID-19. Methods: From February to April 2020, 281 COVID-19 patients who underwent CT at the time of admission were included. We divided the patients into the severe and non-severe disease groups. The severe group included patients with severe pneumonia or critical events. Intensive care unit admission or death were the critical events in this study. We compared the clinical and CT findings between the severe and non-severe groups and investigated the prognostic factors and critical events of the severe group using the regression analysis. Results: Among the 281 patients, 36 (12.8%) patients were in the severe group and 245 (87.2%) patients were in the non-severe group. Critical events occurred in 10 patients (3.6%). In the severe group, patients showed significantly more pneumonia with consolidation, crazy-paving appearance, pleural effusion, and higher CT scores than those in the non-severe group (all, P < 0.05). In the multivariate regression, pleural effusion (odds ratio [OR], 8.96; 95% confidence interval [CI], 1.81-44.42; P = 0.007), CT score > 5 (OR, 3.70; 95% CI, 1.44-9.53; P = 0.007), old age (> 77 years, OR, 9.96; 95% CI, 3.78-26.28; P < 0.001), and elevated C-reactive protein (OR, 4.15; 95% CI, 1.62-10.6; P = 0.003) were significant prognostic factors of severe disease. CT score > 5 (OR, 7.29; 95% CI, 1.37-38.68; P = 0.020), pleural effusion (OR, 5.67; 95% CI, 1.04-30.8; P = 0.045) and old age (OR, 8.6; 95% CI, 1.80-41.0; P = 0.007) were also significant predictors of critical events. Conclusion: Pleural effusion and the extent of pneumonia on initial CT scans are associated with poor prognosis in patients with COVID-19.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAging-
dc.subject.MESHBetacoronavirus-
dc.subject.MESHC-Reactive Protein / analysis-
dc.subject.MESHCoronavirus Infections / diagnosis-
dc.subject.MESHCoronavirus Infections / diagnostic imaging*-
dc.subject.MESHCoronavirus Infections / mortality-
dc.subject.MESHCoronavirus Infections / pathology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHIntensive Care Units-
dc.subject.MESHLung / diagnostic imaging*-
dc.subject.MESHLung / pathology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPandemics-
dc.subject.MESHPleural Effusion / diagnostic imaging*-
dc.subject.MESHPleural Effusion / pathology*-
dc.subject.MESHPneumonia, Viral / diagnosis-
dc.subject.MESHPneumonia, Viral / diagnostic imaging*-
dc.subject.MESHPneumonia, Viral / mortality-
dc.subject.MESHPneumonia, Viral / pathology*-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTomography, X-Ray Computed-
dc.titleAdverse Initial CT Findings Associated with Poor Prognosis of Coronavirus Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학교실)-
dc.contributor.googleauthorYoungJun Chon-
dc.contributor.googleauthorJin Young Kim-
dc.contributor.googleauthorYoung Joo Suh-
dc.contributor.googleauthorJi Yeon Lee-
dc.contributor.googleauthorJae Seok Park-
dc.contributor.googleauthorSung Min Moon-
dc.contributor.googleauthorMu Sook Lee-
dc.contributor.googleauthorJaehyuck Yi-
dc.identifier.doi10.3346/jkms.2020.35.e316-
dc.contributor.localIdA01892-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid32864912-
dc.subject.keywordCOVID-19-
dc.subject.keywordComputed Tomography-
dc.subject.keywordCoronavirus-
dc.subject.keywordPneumonia-
dc.contributor.alternativeNameSuh, Young Joo-
dc.contributor.affiliatedAuthor서영주-
dc.citation.volume35-
dc.citation.number34-
dc.citation.startPagee316-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.35(34) : e316, 2020-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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