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Association between reproductive years and insulin resistance in middle-aged and older women: A 10-year prospective cohort study

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dc.contributor.author권유진-
dc.contributor.author이혜선-
dc.date.accessioned2020-12-11T07:46:02Z-
dc.date.available2020-12-11T07:46:02Z-
dc.date.issued2020-12-
dc.identifier.issn0378-5122-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180648-
dc.description.abstractObjectives: We hypothesized that reproductive years, a marker of total estrogen exposure, may play an important role in insulin resistance. Study design: A total of 3327 middle-aged and older women (age range 40-69 years) from the Korean Genome and Epidemiology Study were included in this large prospective cohort study with a mean follow-up of 10.8 years. Main outcome measures: Insulin resistance and sensitivity were calculated using the homeostatic model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). A linear mixed model for a repeated-measures covariance pattern with unstructured covariance within participants was used to assess longitudinal associations between baseline reproductive years and subsequent changes in HOMA-IR and QUICKI. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for new-onset insulin resistance according to quartiles of reproductive years. Results: Changes in HOMA-IR were significantly greater in Q1 (fewest reproductive years) than in Q4 (most reproductive years) (beta[SE] = 0.038[0.016]; p-value = 0.022), while changes in QUICKI were significantly smaller in Q1 than in Q4 (beta[SE] = -0.001[0.000]; p-value = 0.048) after adjusting for possible confounders over time. Compared with Q1, HRs (95 % CIs) for the incidence of new-onset insulin resistance were 0.807 (0.654-0.994) for Q2, 0.793 (0.645-0.974) for Q3, and 0.770 (0.622-0.953) for Q4 after adjusting for possible confounders. Conclusion: A short reproductive period is associated with elevated levels on the HOMA-IR and decreased levels on the QUICKI over time. The lowest quartile of reproductive years was significantly associated with a higher risk of new-onset insulin resistance.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier/North Holland Biomedical Press-
dc.relation.isPartOfMATURITAS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAssociation between reproductive years and insulin resistance in middle-aged and older women: A 10-year prospective cohort study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorHee Jung Shin-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorYu-Jin Kwon-
dc.identifier.doi10.1016/j.maturitas.2020.07.004-
dc.contributor.localIdA04882-
dc.contributor.localIdA03312-
dc.relation.journalcodeJ02190-
dc.identifier.eissn1873-4111-
dc.identifier.pmid33158485-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0378512220303285-
dc.subject.keywordEstrogen-
dc.subject.keywordInsulin resistance-
dc.subject.keywordInsulin sensitivity-
dc.subject.keywordReproductive years-
dc.subject.keywordWomen-
dc.contributor.alternativeNameKwon, Yu-Jin-
dc.contributor.affiliatedAuthor권유진-
dc.contributor.affiliatedAuthor이혜선-
dc.citation.volume142-
dc.citation.startPage31-
dc.citation.endPage37-
dc.identifier.bibliographicCitationMATURITAS, Vol.142 : 31-37, 2020-12-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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