Cited 3 times in
Association between reproductive years and insulin resistance in middle-aged and older women: A 10-year prospective cohort study
DC Field | Value | Language |
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dc.contributor.author | 권유진 | - |
dc.contributor.author | 이혜선 | - |
dc.date.accessioned | 2020-12-11T07:46:02Z | - |
dc.date.available | 2020-12-11T07:46:02Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 0378-5122 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180648 | - |
dc.description.abstract | Objectives: We hypothesized that reproductive years, a marker of total estrogen exposure, may play an important role in insulin resistance. Study design: A total of 3327 middle-aged and older women (age range 40-69 years) from the Korean Genome and Epidemiology Study were included in this large prospective cohort study with a mean follow-up of 10.8 years. Main outcome measures: Insulin resistance and sensitivity were calculated using the homeostatic model assessment of insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI). A linear mixed model for a repeated-measures covariance pattern with unstructured covariance within participants was used to assess longitudinal associations between baseline reproductive years and subsequent changes in HOMA-IR and QUICKI. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for new-onset insulin resistance according to quartiles of reproductive years. Results: Changes in HOMA-IR were significantly greater in Q1 (fewest reproductive years) than in Q4 (most reproductive years) (beta[SE] = 0.038[0.016]; p-value = 0.022), while changes in QUICKI were significantly smaller in Q1 than in Q4 (beta[SE] = -0.001[0.000]; p-value = 0.048) after adjusting for possible confounders over time. Compared with Q1, HRs (95 % CIs) for the incidence of new-onset insulin resistance were 0.807 (0.654-0.994) for Q2, 0.793 (0.645-0.974) for Q3, and 0.770 (0.622-0.953) for Q4 after adjusting for possible confounders. Conclusion: A short reproductive period is associated with elevated levels on the HOMA-IR and decreased levels on the QUICKI over time. The lowest quartile of reproductive years was significantly associated with a higher risk of new-onset insulin resistance. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier/North Holland Biomedical Press | - |
dc.relation.isPartOf | MATURITAS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association between reproductive years and insulin resistance in middle-aged and older women: A 10-year prospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Hee Jung Shin | - |
dc.contributor.googleauthor | Hye Sun Lee | - |
dc.contributor.googleauthor | Yu-Jin Kwon | - |
dc.identifier.doi | 10.1016/j.maturitas.2020.07.004 | - |
dc.contributor.localId | A04882 | - |
dc.contributor.localId | A03312 | - |
dc.relation.journalcode | J02190 | - |
dc.identifier.eissn | 1873-4111 | - |
dc.identifier.pmid | 33158485 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0378512220303285 | - |
dc.subject.keyword | Estrogen | - |
dc.subject.keyword | Insulin resistance | - |
dc.subject.keyword | Insulin sensitivity | - |
dc.subject.keyword | Reproductive years | - |
dc.subject.keyword | Women | - |
dc.contributor.alternativeName | Kwon, Yu-Jin | - |
dc.contributor.affiliatedAuthor | 권유진 | - |
dc.contributor.affiliatedAuthor | 이혜선 | - |
dc.citation.volume | 142 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 37 | - |
dc.identifier.bibliographicCitation | MATURITAS, Vol.142 : 31-37, 2020-12 | - |
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