The first edition of the guidelines for the use of ultrasound contrast agents was published in 2004, dealing with liver applications. The second
edition of the guidelines in 2008 reflected changes in the available contrast agents and updated the guidelines for the liver, as well as implementing
some nonliver applications. The third edition of the contrast‑enhanced ultrasound (CEUS) guidelines was the joint World Federation for
Ultrasound in Medicine and Biology‑European Federation of Societies for Ultrasound in Medicine and Biology (WFUMB‑EFSUMB) venture
in conjunction with other regional US societies such as Asian Federation of Societies for Ultrasound in Medicine and Biology, resulting in a
simultaneous duplicate on liver CEUS in the official journals of both WFUMB and EFSUMB in 2013. However, no guidelines were described
mainly for Sonazoid due to limited clinical experience only in Japan and Korea. The new proposed consensus statements and recommendations
provide general advice on the use of Sonazoid and are intended to create standard protocols for the use and administration of Sonazoid in
hepatic and pancreatobiliary applications in Asian patients and to improve patient management.