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A mendelian randomization analysis: The causal association between serum uric acid and atrial fibrillation

Authors
 Myunghee Hong  ;  Je-Wook Park  ;  Pil-Sung Yang  ;  Inseok Hwang  ;  Tae-Hoon Kim  ;  Hee Tae Yu  ;  Jae-Sun Uhm  ;  Boyoung Joung  ;  Moon-Hyoung Lee  ;  Sun Ha Jee  ;  Hui-Nam Pak 
Citation
 EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol.50(10) : e13300, 2020-10 
Journal Title
 EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 
ISSN
 0014-2972 
Issue Date
2020-10
Keywords
Mendelian randomization ; atrial fibrillation ; serum uric acid
Abstract
Background: Observational studies have shown that high levels of serum uric acid (UA) were associated with atrial fibrillation (AF). However, the causal effect of urate on the risk of AF is still unknown. To clarify the potential causal association between UA and AF, we performed a Mendelian randomization (MR) analysis using genetic instrumental variables (IVs). Materials and methods: From the Korean GWAS dataset of 633 patients with AF (mean age 50.6 ± 7.8 years, 80.9% male, Yonsei AF Ablation cohort) who underwent radiofrequency catheter ablation and the data from 3533 controls (from the Korea Genome Epidemiology Study), we selected 9 SNPs, with a P value less than .05, associated with an increased UA serum level. Additionally, we calculated the weighted genetic risk score (wGRS) using the selected 9 SNPs, to use it as an instrumental variable. A Mendelian randomization analysis was calculated by a 2-stage estimator method. Results: The conventional association between the serum UA and AF was significant (P = .001) after adjusting for potential confounding factors. The SNP rs1165196 on SLC17A1 (F-statistics = 208.34, 0.18 mg/mL per allele change, P < .001) and wGRS (F-statistics = 222.26, 0.20 mg/mL per 1SD change, P < .001) were significantly associated with an increase in the UA level. The MR analysis was causally associated with rs1165196 (estimated odds ratio (OR), 0.21, 95% confidence interval (CI), 0.06-0.75, P = .017), but not wGRS (estimated OR, 1.07, 95% CI, 0.57-2.01, P = .832). Conclusion: The serum UA level was independently associated with the AF risk.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/eci.13300
DOI
10.1111/eci.13300
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Tae-Hoon(김태훈) ORCID logo https://orcid.org/0000-0003-4200-3456
Park, Je Wook(박제욱)
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
Uhm, Jae Sun(엄재선) ORCID logo https://orcid.org/0000-0002-1611-8172
Yu, Hee Tae(유희태) ORCID logo https://orcid.org/0000-0002-6835-4759
Lee, Moon-Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
Hong, Myunghee(홍명희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180506
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