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A mendelian randomization analysis: The causal association between serum uric acid and atrial fibrillation

DC FieldValueLanguage
dc.contributor.author김태훈-
dc.contributor.author박제욱-
dc.contributor.author박희남-
dc.contributor.author엄재선-
dc.contributor.author유희태-
dc.contributor.author이문형-
dc.contributor.author정보영-
dc.contributor.author지선하-
dc.contributor.author홍민희-
dc.date.accessioned2020-12-01T17:54:29Z-
dc.date.available2020-12-01T17:54:29Z-
dc.date.issued2020-10-
dc.identifier.issn0014-2972-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/180506-
dc.description.abstractBackground: Observational studies have shown that high levels of serum uric acid (UA) were associated with atrial fibrillation (AF). However, the causal effect of urate on the risk of AF is still unknown. To clarify the potential causal association between UA and AF, we performed a Mendelian randomization (MR) analysis using genetic instrumental variables (IVs). Materials and methods: From the Korean GWAS dataset of 633 patients with AF (mean age 50.6 ± 7.8 years, 80.9% male, Yonsei AF Ablation cohort) who underwent radiofrequency catheter ablation and the data from 3533 controls (from the Korea Genome Epidemiology Study), we selected 9 SNPs, with a P value less than .05, associated with an increased UA serum level. Additionally, we calculated the weighted genetic risk score (wGRS) using the selected 9 SNPs, to use it as an instrumental variable. A Mendelian randomization analysis was calculated by a 2-stage estimator method. Results: The conventional association between the serum UA and AF was significant (P = .001) after adjusting for potential confounding factors. The SNP rs1165196 on SLC17A1 (F-statistics = 208.34, 0.18 mg/mL per allele change, P < .001) and wGRS (F-statistics = 222.26, 0.20 mg/mL per 1SD change, P < .001) were significantly associated with an increase in the UA level. The MR analysis was causally associated with rs1165196 (estimated odds ratio (OR), 0.21, 95% confidence interval (CI), 0.06-0.75, P = .017), but not wGRS (estimated OR, 1.07, 95% CI, 0.57-2.01, P = .832). Conclusion: The serum UA level was independently associated with the AF risk.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfEUROPEAN JOURNAL OF CLINICAL INVESTIGATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleA mendelian randomization analysis: The causal association between serum uric acid and atrial fibrillation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMyunghee Hong-
dc.contributor.googleauthorJe-Wook Park-
dc.contributor.googleauthorPil-Sung Yang-
dc.contributor.googleauthorInseok Hwang-
dc.contributor.googleauthorTae-Hoon Kim-
dc.contributor.googleauthorHee Tae Yu-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorHui-Nam Pak-
dc.identifier.doi10.1111/eci.13300-
dc.contributor.localIdA01085-
dc.contributor.localIdA04574-
dc.contributor.localIdA04574-
dc.contributor.localIdA01776-
dc.contributor.localIdA01776-
dc.contributor.localIdA02337-
dc.contributor.localIdA02337-
dc.contributor.localIdA02535-
dc.contributor.localIdA02535-
dc.contributor.localIdA02766-
dc.contributor.localIdA02766-
dc.contributor.localIdA03609-
dc.contributor.localIdA03609-
dc.contributor.localIdA03965-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ00814-
dc.identifier.eissn1365-2362-
dc.identifier.pmid32474920-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/eci.13300-
dc.subject.keywordMendelian randomization-
dc.subject.keywordatrial fibrillation-
dc.subject.keywordserum uric acid-
dc.contributor.alternativeNameKim, Tae-Hoon-
dc.contributor.affiliatedAuthor김태훈-
dc.contributor.affiliatedAuthor박제욱-
dc.contributor.affiliatedAuthor박제욱-
dc.contributor.affiliatedAuthor박희남-
dc.contributor.affiliatedAuthor박희남-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor엄재선-
dc.contributor.affiliatedAuthor유희태-
dc.contributor.affiliatedAuthor유희태-
dc.contributor.affiliatedAuthor이문형-
dc.contributor.affiliatedAuthor이문형-
dc.contributor.affiliatedAuthor정보영-
dc.contributor.affiliatedAuthor정보영-
dc.contributor.affiliatedAuthor지선하-
dc.contributor.affiliatedAuthor지선하-
dc.citation.volume50-
dc.citation.number10-
dc.citation.startPagee13300-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol.50(10) : e13300, 2020-10-
dc.identifier.rimsid67231-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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