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Prevalence and Incidence of Neuromyelitis Optica Spectrum Disorder in Korea: Population Based Study

Authors
 Hye Lim Lee  ;  Jae Young Kim  ;  Jin Myoung Seok  ;  Yoon Ho Hong  ;  Nam Gu Lim  ;  Ha Young Shin  ;  Byung Jo Kim  ;  Soon Young Hwang  ;  Ju Hong Min  ;  Byoung Joon Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.35(17) : e115, 2020-05 
Journal Title
 JOURNAL OF KOREAN MEDICAL SCIENCE 
ISSN
 1011-8934 
Issue Date
2020-05
Keywords
Incidence ; NMOSD ; Neuromyelitis Optica Spectrum Disorder ; Prevalence
Abstract
Background: Although neuromyelitis optica spectrum disorder (NMOSD) is known to be a rare disease, its prevalence and incidence have not yet been studied in Korea. We performed a population-based study to examine the prevalence and incidence of NMOSD in Korea using data from the Korean National Health Insurance (NHI) claims database. Methods: Data from 2013 to 2017 were obtained, with a washout period set as 2013 and 2014. The prevalence and incidence of NMOSD in 2016 and 2017 were calculated using population census data. Subjects were divided into 5 groups at 15-year intervals, depending on the age at which the diagnostic code was entered. The relative risk (RR) for each age group was compared with the oldest (≥ 60 years) age group. Results: The overall prevalence was estimated to be 3.36 and 3.56 per 100,000 individuals, with an incidence of 0.41 and 0.65 per 100,000 individuals-year in 2016 and 2017, respectively. The mean age was 43.08 (standard deviation, 14.56) years, and the ratio of male to females was 1:4.7. The incidence was higher in female individuals aged between 30 and 59 years (RR, 2.8-3.05; P < 0.05). Conclusion: Nationwide prevalence of NMOSD in Korea was 3.36 and 3.56/100,000 and its incidence was 0.41 and 0.65/100,000-year in 2016 and 2017 respectively.
Files in This Item:
T202004666.pdf Download
DOI
10.3346/jkms.2020.35.e115
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Ha Young(신하영) ORCID logo https://orcid.org/0000-0002-4408-8265
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180376
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