Cited 2 times in
MR prediction of pathologic complete response and early-stage rectal cancer after neoadjuvant chemoradiation in patients with clinical T1/T2 rectal cancer for organ saving strategy
DC Field | Value | Language |
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dc.contributor.author | 금웅섭 | - |
dc.contributor.author | 김남규 | - |
dc.contributor.author | 김명진 | - |
dc.contributor.author | 배희진 | - |
dc.contributor.author | 서니은 | - |
dc.contributor.author | 임준석 | - |
dc.date.accessioned | 2020-12-01T17:39:59Z | - |
dc.date.available | 2020-12-01T17:39:59Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180373 | - |
dc.description.abstract | To evaluate the ability of magnetic resonance imaging (MRI) to predict pathologic complete response (pCR) after neoadjuvant chemoradiation therapy (CRT) in patients with clinical T1/T2 rectal cancer to indicate candidates for organ-saving strategies.Between 2012 and 2016, 38 patients with clinical T1/T2 rectal cancer received neoadjuvant CRT. Radiologic complete response (rCR) was assigned when dense fibrotic tissue without tumor signal intensity was observed on post-CRT MRI. Surgical pathologic assessment was used to evaluate tumor regression. The association between rCR and the mural extent of the primary tumor, pCR, and pathologic T stage were analyzed.In rCR patients, the pCR rate was higher; the odds of achieving pCR were 8.00 times higher than for non-rCR patients (P = .02). rCR patients were also more likely to have early-stage cancer than non-rCR patients (P = 0.01). Patients with partial extent of the primary tumor on post-CRT MRI were more likely to be diagnosed with early-stage cancer than those with transmural extent (P = .01).rCR indicated by post-CRT MRI can be used as a supportive factor to predict pCR after neoadjuvant CRT in patients with clinical T1/T2 rectal cancer and can guide management decisions around organ-saving treatments. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Chemoradiotherapy | - |
dc.subject.MESH | Early Detection of Cancer | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoadjuvant Therapy | - |
dc.subject.MESH | Organ Sparing Treatments | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Rectal Neoplasms / diagnostic imaging* | - |
dc.subject.MESH | Rectal Neoplasms / pathology | - |
dc.subject.MESH | Rectal Neoplasms / therapy* | - |
dc.subject.MESH | Remission Induction* | - |
dc.title | MR prediction of pathologic complete response and early-stage rectal cancer after neoadjuvant chemoradiation in patients with clinical T1/T2 rectal cancer for organ saving strategy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Heejin Bae | - |
dc.contributor.googleauthor | Nieun Seo | - |
dc.contributor.googleauthor | Kyunghwa Han | - |
dc.contributor.googleauthor | Woong Sub Koom | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.contributor.googleauthor | Nam Kyu Kim | - |
dc.contributor.googleauthor | Joon Seok Lim | - |
dc.identifier.doi | 10.1097/MD.0000000000022746 | - |
dc.contributor.localId | A00273 | - |
dc.contributor.localId | A00353 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A05346 | - |
dc.contributor.localId | A01874 | - |
dc.contributor.localId | A03408 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 33080736 | - |
dc.contributor.alternativeName | Koom, Woong Sub | - |
dc.contributor.affiliatedAuthor | 금웅섭 | - |
dc.contributor.affiliatedAuthor | 김남규 | - |
dc.contributor.affiliatedAuthor | 김명진 | - |
dc.contributor.affiliatedAuthor | 배희진 | - |
dc.contributor.affiliatedAuthor | 서니은 | - |
dc.contributor.affiliatedAuthor | 임준석 | - |
dc.citation.volume | 99 | - |
dc.citation.number | 42 | - |
dc.citation.startPage | e22746 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.99(42) : e22746, 2020-10 | - |
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