Cited 19 times in
Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진우 | - |
dc.contributor.author | 박미나 | - |
dc.contributor.author | 서상현 | - |
dc.contributor.author | 안성준 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2020-12-01T17:39:02Z | - |
dc.date.available | 2020-12-01T17:39:02Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180367 | - |
dc.description.abstract | Objectives: Aging is a major risk factor for many neurological disorders and is associated with dural lymphatic dysfunction. We sought to evaluate the association of aging with the volume of the peri-sinus lymphatic space using contrast-enhanced 3T T1-weighted black-blood magnetic resonance imaging (MRI). Methods: In this retrospective study, 165 presumed neurologically normal subjects underwent brain MRIs for cancer staging between April and November 2018. The parasagittal peri-sinus lymphatic space was evaluated using contrast-enhanced 3D T1-weighted black-blood MRIs, and volumes were measured with semiautomatic method. We compared the volumes of normalized peri-sinus lymphatic spaces between the elderly (≥65 years, n = 72) and non-elderly (n = 93) groups and performed multivariate logistic regression analyses to assess if aging is independently associated with the volume of normalized peri-sinus lymphatic spaces. Results: The normalized peri-sinus lymphatic space volume was significantly higher in the elderly than in the non-elderly (mean, 3323 ± 758.7 mL vs. 2968.7 ± 764.3 mL, p = 0.047). After adjusting the intracranial volume, age age was the strongest factor independently associated with peri-sinus lymphatic space volume (β coefficient, 28.4 (5.7-51.2), p = 0.015) followed by male sex (β coefficient, 672.4 (113.5-1230.8), p = 0.019). Conclusions: We found that the peri-sinus dural lymphatic space volume was higher in the elderly group than in the non-elderly group, and the increased peri-sinus lymphatic space was independently associated with aging. These findings indicate that the peri-sinus lymphatic space may be related with the aging process and lymphatic system dysfunction as well. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Aging Is Positively Associated with Peri-Sinus Lymphatic Space Volume: Assessment Using 3T Black-Blood MRI | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학교실) | - |
dc.contributor.googleauthor | Mina Park | - |
dc.contributor.googleauthor | Jin Woo Kim | - |
dc.contributor.googleauthor | Sung Jun Ahn | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Sang Hyun Suh | - |
dc.identifier.doi | 10.3390/jcm9103353 | - |
dc.contributor.localId | A01027 | - |
dc.contributor.localId | A01460 | - |
dc.contributor.localId | A01886 | - |
dc.contributor.localId | A02237 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 33086702 | - |
dc.subject.keyword | dural lymphatics | - |
dc.subject.keyword | glymphatic system | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.subject.keyword | meninges | - |
dc.contributor.alternativeName | Kim, Jin Woo | - |
dc.contributor.affiliatedAuthor | 김진우 | - |
dc.contributor.affiliatedAuthor | 박미나 | - |
dc.contributor.affiliatedAuthor | 서상현 | - |
dc.contributor.affiliatedAuthor | 안성준 | - |
dc.contributor.affiliatedAuthor | 차윤진 | - |
dc.citation.volume | 9 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 3353 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.9(10) : 3353, 2020-10 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.