Cited 1 times in
SLAMF1 contributes to cell survival through the AKT signaling pathway in Farage cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김응권 | - |
dc.contributor.author | 윤희제 | - |
dc.date.accessioned | 2020-12-01T17:32:41Z | - |
dc.date.available | 2020-12-01T17:32:41Z | - |
dc.date.issued | 2020-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/180324 | - |
dc.description.abstract | SLAMF1 is often overexpressed in Epstein Barr virus (EBV)-infected B cell tumors. However, its role in the pathogenesis of EBV-infected B cell tumors remains largely unknown. Here, we generated SLAMF1-deficient EBV+ tumor cells and examined the effect of its deficiency on cell proliferation and cell survival. There were no significant differences in cell proliferation and cell cycle distribution for short periods between the SLAMF1-deficient and wild-type cells. However, the deficient cells were more resistant to an AKT inhibitor (MK-2206). When the both cells were co-cultured and repeatedly exposed to the limitations in nutrition and growth factors, the SLAMF1-deficient cells were gradually decreased. We observed that levels of phospho-AKT were differentially regulated according to the nutritional status between the SLAMF1-deficient and wild-type cells. A decrease in phospho-AKT was observed in SLAMF1-deficient cells as well as an increase in pro-apoptotic Bim just before cell passage, which may have been due to the loss of SLAMF1 under poor growth condition. Overall, SLAMF1 is not a strong survival factor, but it seems to be necessary for cell survival in unfavorable growth condition. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | B-Lymphocytes / metabolism | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Herpesvirus 4, Human / metabolism | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Proto-Oncogene Proteins c-akt / metabolism* | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Signaling Lymphocytic Activation Molecule Family Member 1 / metabolism* | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | SLAMF1 contributes to cell survival through the AKT signaling pathway in Farage cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Heejei Yoon | - |
dc.contributor.googleauthor | Eung Kweon Kim | - |
dc.contributor.googleauthor | Young Hyeh Ko | - |
dc.identifier.doi | 10.1371/journal.pone.0238791 | - |
dc.contributor.localId | A00831 | - |
dc.contributor.localId | A05929 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 32886706 | - |
dc.contributor.alternativeName | Kim, Eung Kweon | - |
dc.contributor.affiliatedAuthor | 김응권 | - |
dc.contributor.affiliatedAuthor | 윤희제 | - |
dc.citation.volume | 15 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e0238791 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.15(9) : e0238791, 2020-09 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.