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Innate immune receptors in type 1 diabetes: the relationship to cell death-associated inflammation

Authors
 Tae Kang Kim  ;  Myung-Shik Lee 
Citation
 BIOCHEMICAL SOCIETY TRANSACTIONS, Vol.48(3) : 1213-1225, 2020-06 
Journal Title
 BIOCHEMICAL SOCIETY TRANSACTIONS 
ISSN
 0300-5127 
Issue Date
2020-06
Keywords
Toll-like receptors ; cell death ; innate immunity
Abstract
The importance of innate immunity in host defense and inflammatory responses has been clearly demonstrated after the discovery of innate immune receptors such as Toll-like receptors (TLRs) or Nucleotide-binding oligomerization domain-containing protein (Nod)-like receptors (NLRs). Innate immunity also plays a critical role in diverse pathological conditions including autoimmune diseases such as type 1 diabetes (T1D). In particular, the role of a variety of innate immune receptors in T1D has been demonstrated using mice with targeted disruption of such innate immune receptors. Here, we discuss recent findings showing the role of innate immunity in T1D that were obtained mostly from studies of genetic mouse models of innate immune receptors. In addition, the role of innate immune receptors involved in the pathogenesis of T1D in sensing death-associated molecular patterns (DAMPs) released from dead cells or pathogen-associated molecular patterns (PAMPs) will also be covered. Elucidation of the role of innate immune receptors in T1D and the nature of DAMPs sensed by such receptors may lead to the development of new therapeutic modalities against T1D.
Full Text
https://portlandpress.com/biochemsoctrans/article/48/3/1213/225192/Innate-immune-receptors-in-type-1-diabetes-the
DOI
10.1042/BST20200131
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Lee, Myung Shik(이명식) ORCID logo https://orcid.org/0000-0003-3292-1720
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/180291
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